Attribute	Manifest Name	Description	Required	Conditional If	Data Type	Valid Values
HTAN Participant ID	Demographics,Diagnosis,Exposure,Family History,Follow Up,Molecular Test,Participant Vital Status Update,Therapy,Clinical Data Tier 2,Acute Lymphoblastic Leukemia Tier 3,Breast Cancer Tier 3,Colorectal Cancer Tier 3,Lung Cancer Tier 3,Melanoma Tier 3,Ovarian Cancer Tier 3,Pancreatic Cancer Tier 3,Prostate Cancer Tier 3,Sarcoma Tier 3	HTAN ID associated with a patient based on HTAN ID SOP (eg HTANx_yyy )	True		String	
Ethnicity	Demographics	An individual's self-described social and cultural grouping, specifically whether an individual describes themselves as Hispanic or Latino. The provided values are based on the categories defined by the U.S. Office of Management and Business and used by the U.S. Census Bureau.	True		String	hispanic or latino not hispanic or latino unknown Not Reported not allowed to collect
Gender	Demographics	Text designations that identify gender. Gender is described as the assemblage of properties that distinguish people on the basis of their societal roles. [Identification of gender is based upon self-report and may come from a form, questionnaire, interview, etc.]	True		String	Female Male unknown Unspecified Not Reported
Race	Demographics	An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation withina a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.	True		String	white american indian or alaska native black or african american asian native hawaiian or other pacific islander Other unknown Not Reported not allowed to collect
Vital Status	Demographics,Participant Vital Status Update	The survival state of the person registered on the protocol.	True		String	Alive Dead unknown Not Reported
Days to Birth	Demographics	Number of days between the date used for index and the date from a person's date of birth represented as a calculated negative number of days. If not applicable please enter 'Not Applicable'	False		String	
Country of Residence	Demographics	Country of Residence at enrollment	False		String	Afghanistan Albania Algeria Andorra Angola Anguilla Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Brazil Brunei Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Colombia Comoros Congo Cook Islands Costa Rica Cote d'Ivoire Croatia Cuba Curacao Cyprus Czech Republic (Czechia) Democratic Republic of the Congo Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Eswatini Ethiopia Falkland Islands (Malvinas) Faroe Islands Federated States of Micronesia Fiji Finland France French Guiana French Polynesia Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Holy See Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Kosovo Kuwait Kyrgyzstan Laos Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macau Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue North Korea North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Panama Papua New Guinea Paraguay Peru Philippines Poland Portugal Puerto Rico Qatar Reunion Romania Russia Rwanda Saint Helena Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Korea South Sudan Spain Sri Lanka State of Palestine Sudan Suriname Svalbard & Jan Mayen Islands Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela Vietnam Virgin Islands British Virgin Islands U.S. Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe
Age Is Obfuscated	Demographics	The age of the patient has been modified for compliance reasons. The actual age differs from what is reported. Other date intervals for this patient may also be modified.	False		String	true false
Year Of Birth	Demographics	Numeric value to represent the calendar year in which an individual was born.	False		String	
Occupation Duration Years	Demographics	The number of years a patient worked in a specific occupation.	False		String	
Premature At Birth	Demographics	The yes/no/unknown indicator used to describe whether the patient was premature (less than 37 weeks gestation) at birth.	False		String	yes no unknown Not Reported
Weeks Gestation at Birth	Demographics	Numeric value used to describe the number of weeks starting from the approximate date of the biological mother's last menstrual period and ending with the birth of the patient.	False		String	
Dead	Demographics	This indicates the participant is dead and defines further required metadata	False		String	
Year of Death	Demographics	Numeric value to represent the year of the death of an individual.	True	Vital Status is "Dead"	String	
Cause of Death	Demographics	The cause of death	True	Vital Status is "Dead"	String	Cancer Related Cardiovascular Disorder NOS End-stage Renal Disease Infection Not Cancer Related Renal Disorder NOS Spinal Muscular Atrophy Surgical Complications Toxicity Not Reported unknown Not Applicable
Cause of Death Source	Demographics	The text term used to describe the source used to determine the patient's cause of death.	False	Vital Status is "Dead"	String	Autopsy Death Certificate Medical Record Social Security Death Index Obituary unknown Not Reported
Days to Death	Demographics	Number of days between the date used for index and the date from a person's date of death represented as a calculated number of days. If not applicable please enter 'Not Applicable'	False	Vital Status is "Dead"	String	
Age at Diagnosis	Diagnosis	Age at the time of diagnosis expressed in number of days since birth.	True		String	
Year of Diagnosis	Diagnosis	Numeric value to represent the year of an individual's initial pathologic diagnosis of cancer.	False		String	
Primary Diagnosis	Diagnosis	Text term used to describe the patient's histologic diagnosis, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).	True		String	Acinar cell carcinoma Acute basophilic leukaemia Acute leukemia Burkitt type Acute leukemia NOS Acute lymphatic leukemia Acute lymphoblastic leukemia-lymphoma NOS Acute lymphoblastic leukemia mature B-cell type Acute lymphoblastic leukemia NOS Acute lymphoblastic leukemia precursor cell type Acute lymphocytic leukemia Acute lymphoid leukemia Acute myeloid leukemia minimal differentiation Acute myeloid leukemia MLL Acute myeloid leukemia NOS Acute myelomonocytic leukemia Acute promyelocytic leukemia NOS Adenocarcinoid tumor Adenocarcinoma combined with other types of carcinoma Adenocarcinoma in a polyp NOS Adenocarcinoma in adenomatous polyp Adenocarcinoma in polypoid adenoma Adenocarcinoma in situ in a polyp NOS Adenocarcinoma in situ in adenomatous polyp Adenocarcinoma in situ in tubular adenoma Adenocarcinoma in situ mucinous Adenocarcinoma in situ non-mucinous Adenocarcinoma in situ NOS Adenocarcinoma in tubular adenoma Adenocarcinoma in villous adenoma Adenocarcinoma of anal ducts Adenocarcinoma of anal glands Adenocarcinoma diffuse type Adenocarcinoma endocervical type Adenocarcinoma intestinal type Adenocarcinoma metastatic NOS Adenocarcinoma NOS Adenocarcinoma pancreatobiliary type Adult rhabdomyoma Adult T-cell lymphoma Adult T-cell lymphoma/leukemia Astrocytoma anaplastic Astrocytoma low grade Astrocytoma NOS B cell lymphoma NOS B lymphoblastic leukemia/lymphoma with hyperdiploidy B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL) B lymphoblastic leukemia/lymphoma NOS B-ALL B-cell lymphocytic leukemia/small lymphocytic lymphoma Basal cell adenocarcinoma Basal cell adenoma Basal cell carcinoma NOS Basal cell epithelioma Basal cell tumor Basophil adenocarcinoma Basophil adenoma Basophil carcinoma Bile duct adenocarcinoma Bile duct adenoma Bile duct carcinoma Bile duct cystadenocarcinoma Bile duct cystadenoma Bronchial adenoma carcinoid Bronchial adenoma cylindroid Bronchial adenoma NOS Bronchial-associated lymphoid tissue lymphoma Bronchio-alveolar carcinoma mixed mucinous and non-mucinous Bronchio-alveolar carcinoma mucinous Bronchiolar adenocarcinoma Bronchiolar carcinoma Bronchiolo-alveolar adenocarcinoma NOS Bronchiolo-alveolar carcinoma Clara cell Bronchiolo-alveolar carcinoma Clara cell and goblet cell type Bronchiolo-alveolar carcinoma goblet cell type Bronchiolo-alveolar carcinoma indeterminate type Bronchiolo-alveolar carcinoma non-mucinous Bronchiolo-alveolar carcinoma NOS Burkitt cell leukemia Burkitt lymphoma NOS (Includes all variants) Burkitt tumor Burkitt-like lymphoma c-ALL Cancer Capillary hemangioma Capillary lymphangioma Carcinoma in a polyp NOS Carcinoma in adenomatous polyp Carcinoma in pleomorphic adenoma Carcinoma in situ in a polyp NOS Carcinoma in situ in adenomatous polyp Carcinoma in situ NOS Carcinoma anaplastic NOS Carcinoma diffuse type Carcinoma intestinal type Carcinoma metastatic NOS Carcinoma NOS Carcinosarcoma NOS Carcinoma undifferentiated NOS Cementoma NOS Central neuroblastoma Central neurocytoma Cerebellar liponeurocytoma Cerebellar sarcoma NOS Cervical intraepithelial neoplasia grade III Cervical intraepithelial neoplasia low grade Chondroma NOS Chondrosarcoma grade 2/3 Chronic granulocytic leukemia BCR/ABL Chronic granulocytic leukemia NOS Chronic granulocytic leukemia Philadelphia chromosome (Ph1) positive Chronic leukemia NOS Chronic lymphatic leukemia Chronic lymphocytic leukemia Chronic lymphocytic leukemia B-cell type (includes all variants of BCLL) Chronic lymphoid leukemia Chronic monocytic leukemia Chronic myelocytic leukemia NOS Chronic myelogenous leukemia BCR-ABL positive Chronic myelogenous leukemia Philadelphia chromosome (Ph 1) positive Chronic myeloid leukemia NOS Chronic myelomonocytic leukemia in transformation Chronic myelomonocytic leukemia NOS Chronic myelomonocytic leukemia Type 1 Chronic myelomonocytic leukemia Type II Chronic myeloproliferative disease NOS Chronic myeloproliferative disorder Chronic neutrophilic leukemia Classical Hodgkin lymphoma lymphocyte depletion diffuse fibrosis Classical Hodgkin lymphoma lymphocyte depletion NOS Classical Hodgkin lymphoma lymphocyte depletion reticular Classical Hodgkin lymphoma lymphocyte-rich Classical Hodgkin lymphoma mixed cellularity NOS Classical Hodgkin lymphoma nodular sclerosis cellular phase Classical Hodgkin lymphoma nodular sclerosis grade 1 Classical Hodgkin lymphoma nodular sclerosis grade 2 Classical Hodgkin lymphoma nodular sclerosis NOS Combined hepatocellular carcinoma and cholangiocarcinoma Combined large cell neuroendocrine carcinoma Combined small cell carcinoma Combined small cell-adenocarcinoma Combined small cell-large carcinoma Combined small cell-squamous cell carcinoma Combined/mixed carcinoid and adenocarcinoma Composite Hodgkin and non-Hodgkin lymphoma Dermal nevus Dermatofibroma NOS Diffuse astrocytoma IDH-mutant Diffuse astrocytoma IDH-wildtype Diffuse astrocytoma low grade Diffuse large B-cell lymphoma NOS Diffuse melanocytosis Duct adenocarcinoma NOS Duct adenoma NOS Duct carcinoma desmoplastic type Duct carcinoma NOS Duct cell carcinoma Ductal carcinoma in situ NOS Ductal carcinoma NOS Dysplastic nevus Endometrial sarcoma NOS Endometrioid adenocarcinoma NOS Endometrioid adenofibroma NOS Endometrioid adenoma NOS Endometrioid carcinoma NOS Eosinophil adenocarcinoma Eosinophil adenoma Eosinophil carcinoma Eosinophilic granuloma Eosinophilic leukemia Ependymoma NOS Epidermoid carcinoma in situ NOS Epidermoid carcinoma NOS Epithelial tumor benign Epithelial tumor malignant Esophageal glandular dysplasia (intraepithelial neoplasia) high grade Esophageal glandular dysplasia (intraepithelial neoplasia) low grade Esophageal intraepithelial neoplasia high grade Esophageal squamous intraepithelial neoplasia (dysplasia) high grade Esophageal squamous intraepithelial neoplasia (dysplasia) low grade Ewing sarcoma Ganglioglioma NOS Familial adenomatous polyposis Gastrin cell tumor Gastrin cell tumor malignant Gastrinoma malignant Gastrinoma NOS Gastrointestinal stromal tumor malignant Glioblastoma Glioma malignant Glioma NOS Haemangioblastoma Haemangiosarcoma Hepatocarcinoma Hepatocellular adenoma Hepatocellular carcinoma NOS Hepatocholangiocarcinoma Hepatoid adenocarcinoma Hepatoid carcinoma Hodgkin disease NOS Hodgkin granuloma Hodgkin lymphoma mixed cellularity NOS Hodgkin lymphoma nodular sclerosis NOS Hodgkin lymphoma NOS Hodgkin paragranuloma NOS Hodgkin sarcoma Infiltrating basal cell carcinoma NOS Infiltrating duct carcinoma NOS Infiltrating duct and colloid carcinoma Infiltrating duct and cribriform carcinoma Inflammatory adenocarcinoma Inflammatory carcinoma Interstitial cell tumor benign Interstitial cell tumor malignant Interstitial cell tumor NOS Intracystic papilloma Intradermal nevus Intraductal adenocarcinoma noninfiltrating NOS Intraductal and lobular carcinoma Intraductal carcinoma and lobular carcinoma in situ Intraductal carcinoma clinging Intraductal carcinoma noninfiltrating NOS Intraductal carcinoma NOS Intraductal carcinoma solid type Intraductal micropapillary carcinoma Intraductal papillary adenocarcinoma with invasion Intraductal papillary adenocarcinoma NOS Intraductal papillary carcinoma Intraductal tubular-papillary neoplasm high grade Intraductal tubular-papillary neoplasm low grade Intraductal tubulopapillary neoplasm Intraepidermal carcinoma NOS Intraepidermal squamous cell carcinoma Bowen type Intravascular B-cell lymphoma Juvenile myelomonocytic leukemia Kaposi sarcoma Large cell carcinoma NOS Liposarcoma differentiated Liposarcoma NOS Liposarcoma well differentiated Liver cell adenoma Liver cell carcinoma Lobular adenocarcinoma Lobular and ductal carcinoma Lobular carcinoma in situ NOS Lobular carcinoma noninfiltrating Lobular carcinoma NOS Lymphatic leukemic NOS Lymphoblastic leukemia NOS Lymphoblastoma Lymphocytic leukemia NOS Lymphoma NOS Malignancy Malignant lymphoma diffuse NOS Malignant lymphoma Hodgkin Malignant lymphoma immunoblastic NOS Malignant lymphoma large B-cell diffuse NOS Malignant lymphoma large B-cell NOS Malignant lymphoma large cell NOS Malignant lymphoma lymphoblastic NOS Malignant lymphoma lymphocytic diffuse NOS Malignant lymphoma lymphocytic nodular NOS Malignant lymphoma lymphocytic NOS Malignant lymphoma mixed cell type diffuse Malignant lymphoma mixed cell type follicular Malignant lymphoma mixed cell type nodular Malignant lymphoma nodular NOS Malignant lymphoma non-Hodgkin NOS Malignant lymphoma NOS Malignant lymphoma small B lymphocytic NOS Malignant melanoma in congenital melanocytic nevus Malignant melanoma in giant pigmented nevus Malignant melanoma in Hutchinson melanotic freckle Malignant melanoma in junctional nevus Malignant melanoma in precancerous melanosis Malignant melanoma NOS Malignant melanoma regressing Mammary carcinoma in situ Medullary adenocarcinoma Medullary carcinoma NOS Medullary osteosarcoma Medulloblastoma NOS Melanoameloblastoma Melanocytic nevus Melanocytoma eyeball Melanocytoma NOS Melanoma in situ Melanoma malignant of soft parts Melanoma NOS Melanotic medulloblastoma Melanotic MPNST Melanotic neuroectodermal tumor Melanotic neurofibroma Melanotic progonoma Melanotic psammomatous MPNST Melanotic schwannoma Meningeal melanocytoma Meningeal melanoma Meningioma anaplastic Meningioma malignant Meningioma NOS Micropapillary carcinoma NOS Mixed adenocarcinoma and epidermoid carcinoma Mixed adenocarcinoma and squamous cell carcinoma Mixed medullary-follicular carcinoma Mixed medullary-papillary carcinoma Mixed pancreatic endocrine and exocrine tumor malignant Mixed pineal tumor Mixed small cell carcinoma Mixed squamous cell and glandular papilloma Mixed tumor malignant NOS Mixed tumor NOS Monocytic leukemia NOS Mucosal-associated lymphoid tissue lymphoma Mucous adenocarcinoma Multiple myeloma Myelocytic leukemia NOS Myeloid leukemia NOS Myeloma NOS Myoepithelioma Neoplasm benign Neoplasm malignant Neoplasm malignant uncertain whether primary or metastatic Neoplasm metastatic Neoplasm NOS Neoplasm secondary Neoplasm uncertain whether benign or malignant Nephroblastoma NOS Neuroblastoma NOS Neuroendocrine carcinoma NOS Neuroepithelioma NOS Neurofibroma NOS Neurofibromatosis NOS Neurofibrosarcoma Neurosarcoma Nevus NOS Non-Hodgkin lymphoma NOS Non-invasive low grade serous carcinoma Non-lymphocytic leukemia NOS Non-small cell carcinoma Nonpigmented nevus Not Reported Oat cell carcinoma Osteoblastoma malignant Osteoblastoma NOS Osteosarcoma NOS Paget disease and infiltrating duct carcinoma of breast Paget disease and intraductal carcinoma of breast Paget disease of breast Paget disease extramammary Paget disease mammary Pagetoid reticulosis Pancreatic endocrine tumor benign Pancreatic endocrine tumor malignant Pancreatic endocrine tumor nonfunctioning Pancreatic endocrine tumor NOS Pancreatic microadenoma Pancreatobiliary neoplasm non-invasive Pancreatobiliary-type carcinoma Pancreatoblastoma Papillary adenocarcinoma follicular variant Papillary adenocarcinoma NOS Papillary adenofibroma Papillary adenoma NOS Papillary and follicular carcinoma Papillary carcinoma in situ Papillary carcinoma NOS Papillary cystadenoma NOS Papillary epidermoid carcinoma Papillary glioneuronal tumor Papillary meningioma Papillary microcarcinoma Papillary renal cell carcinoma Papillary serous adenocarcinoma Papillary serous cystadenocarcinoma Papillary serous cystadenoma NOS Papillary squamous cell carcinoma Papillary squamous cell carcinoma in situ Papillary transitional cell carcinoma Papillary tumor of the pineal region Papillary urothelial carcinoma Papilloma of bladder Papilloma NOS Papillomatosis glandular Papillomatosis NOS Papillotubular adenocarcinoma Papillotubular adenoma Paraganglioma benign Paraganglioma malignant Paraganglioma NOS Peripheral T-cell lymphoma large cell Peripheral T-cell lymphoma NOS Pigmented adenoma Pigmented basal cell carcinoma Pigmented nevus NOS Pituitary adenoma NOS Pituitary carcinoma NOS Pleomorphic adenoma Pleomorphic carcinoma Pleomorphic lipoma Pleomorphic liposarcoma Pleomorphic lobular carcinoma Pleomorphic lobular carcinoma in situ Precancerous melanosis NOS Precursor B-cell lymphoblastic leukemia Precursor B-cell lymphoblastic lymphoma Precursor cell lymphoblastic leukemia NOS Precursor T-cell lymphoblastic leukemia Precursor T-cell lymphoblastic lymphoma Preleukemia Preleukemic syndrome Primary amyloidosis Pro-B ALL Pro-T ALL Prostatic intraepithelial neoplasia grade III Pulmonary adenomatosis Pulmonary artery intimal sarcoma Pulmonary blastoma Renal carcinoma collecting duct type Renal cell adenocarcinoma Renal cell carcinoma chromophobe type Renal cell carcinoma NOS Renal cell carcinoma sarcomatoid Renal cell carcinoma spindle cell Renal cell carcinoma unclassified Renal medullary carcinoma Rhabdoid meningioma Rhabdoid sarcoma Rhabdoid tumor NOS Rhabdomyoma NOS Rhabdomyosarcoma with ganglionic differentiation Rhabdomyosarcoma NOS Rhabdosarcoma Rodent ulcer Sarcoma NOS Sclerosing hemangioma Sclerosing hepatic carcinoma Secondary carcinoma Secretory carcinoma of breast Serous cystadenocarcinoma NOS Serous surface papillary carcinoma High-grade serous carcinoma Skin appendage carcinoma Small cell carcinoma NOS Small cell neuroendocrine carcinoma Small cell osteosarcoma Small cell sarcoma Small congenital nevus Spindle cell carcinoma NOS Spindle cell melanoma NOS Splenic B-cell lymphoma/leukemia unclassifiable Splenic diffuse red pulp small B-cell lymphoma Splenic lymphoma with villous lymphocytes Splenic marginal zone B-cell lymphoma Splenic marginal zone lymphoma NOS Squamous cell carcinoma in situ NOS Squamous cell carcinoma adenoid Squamous cell carcinoma clear cell type Squamous cell carcinoma NOS T lymphoblastic leukemia/lymphoma T-cell large granular lymphocytic leukemia T-cell large granular lymphocytosis T-cell lymphoma NOS Teratoma malignant NOS Teratoma NOS Therapy related myeloid neoplasm Transitional carcinoma Transitional cell carcinoma Transitional cell carcinoma in situ Tubular adenocarcinoma Tubular adenoma NOS Tubular androblastoma with lipid storage Tubular androblastoma NOS Tubular carcinoid Tubular carcinoma Tubulo-papillary adenoma Tubulocystic renal cell carcinoma Tubulolobular carcinoma Tubulopapillary adenocarcinoma Tubulovillous adenoma NOS Tumor cells benign Tumor cells malignant Tumor cells NOS Tumor cells uncertain whether benign or malignant Tumor embolus Tumor benign Tumor malignant NOS Tumor metastatic Tumor NOS Tumor secondary Tumorlet benign Typical carcinoid Unclassified tumor benign Unclassified tumor borderline malignancy Unclassified tumor malignant Unclassified tumor malignant uncertain whether primary or metastatic Unclassified tumor uncertain whether benign or malignant Undifferentiated epithelioid sarcoma Undifferentiated high-grade pleomorphic sarcoma Undifferentiated leukaemia Undifferentiated pleomorphic sarcoma Undifferentiated round cell sarcoma Undifferentiated sarcoma Undifferentiated spindle cell sarcoma Undifferentiated uterine sarcoma unknown
Precancerous Condition Type	Diagnosis	The classification of pre-cancerous cells found in a specific collection of data being studied by the Consortium for Molecular and Cellular Characterization of Screen-Detected Lesions (MCL).	False		String	Ductal Carcinoma In Situ Pancreatic Intraductal Papillary-Mucinous Neoplasm Atypical Adenomatous Lung Hyperplasia Other Pancreatic Intraepithelial Neoplasia Prostatic Intraepithelial Neoplasia Melanocytic hyperplasia Atypical melanocytic proliferation Melanoma in situ Superficial spreading Lentigo maligna type Acral-lentiginous Melanoma in situ arising in a giant congenital nevus Persistent melanoma in situ Melanoma in situ not otherwise classified Scar - no residual melanoma Invasive melanoma - superficial spreading Invasive melanoma - nodular type Invasive melanoma - lentigo maligna Invasive melanoma - acral lentiginous Invasive melanoma - desmoplastic Invasive melanoma - nevoid Invasive melanoma Normal WDA Reserve cell hyperplasia Squamous metaplasia - mature Squamous metaplasia - immature Mild dysplasia Moderate dysplasia Severe dysplasia Atypical adenomatous hyperplasia Adenocarcinoma in situ - non mucinous Adenocarcinoma in situ - mucinous Benign tumor NOS Hamartoma Carcinoma NOS Normal Squamous carcinoma in situ Neuroendocrine cell hyperplasia No diagnosis possible Not Applicable
Site of Resection or Biopsy	Diagnosis	The text term used to describe the anatomic site of the resection or biopsy of the patient's malignant disease, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).	True	Biospecimen is "Bone"' 'Biospecimen is "Tissue"' 'Biospecimen is "Urine"	String	Abdomen NOS Abdominal esophagus Accessory sinus NOS Acoustic nerve Adrenal gland NOS Ampulla of Vater Anal canal Anterior 2/3 of tongue NOS Anterior floor of mouth Anterior mediastinum Anterior surface of epiglottis Anterior wall of bladder Anterior wall of nasopharynx Anus NOS Aortic body and other paraganglia Appendix Ascending colon Autonomic nervous system NOS Axillary tail of breast Base of tongue NOS Bladder neck Bladder NOS Blood Body of pancreas Body of penis Body of stomach Bone marrow Bone of limb NOS Bone NOS Bones of skull and face and associated joints Border of tongue Brain stem Brain NOS Branchial cleft Breast NOS Broad ligament Cardia NOS Carotid body Cauda equina Cecum Central portion of breast Cerebellum NOS Cerebral meninges Cerebrum Cervical esophagus Cervix uteri Choroid Ciliary body Cloacogenic zone Colon NOS Commissure of lip Conjunctiva Connective subcutaneous and other soft tissues of abdomen Connective subcutaneous and other soft tissues of head face and neck Connective subcutaneous and other soft tissues of lower limb and hip Connective subcutaneous and other soft tissues of pelvis Connective subcutaneous and other soft tissues of thorax Connective subcutaneous and other soft tissues of trunk NOS Connective subcutaneous and other soft tissues of upper limb and shoulder Connective subcutaneous and other soft tissues NOS Cornea NOS Corpus uteri Cortex of adrenal gland Cranial nerve NOS Craniopharyngeal duct Descended testis Descending colon Dome of bladder Dorsal surface of tongue NOS Duodenum Endocervix Endocrine gland NOS Endometrium Epididymis Esophagus NOS Ethmoid sinus Exocervix External ear External lip NOS External lower lip External upper lip Extrahepatic bile duct Eye NOS Eyelid Fallopian tube Female genital tract NOS Floor of mouth NOS Frontal lobe Frontal sinus Fundus of stomach Fundus uteri Gallbladder Gastric antrum Gastrointestinal tract NOS Glans penis Glottis Greater curvature of stomach NOS Gum NOS Hard palate Head of pancreas Head face or neck NOS Heart Hematopoietic system NOS Hepatic flexure of colon Hypopharyngeal aspect of aryepiglottic fold Hypopharynx NOS Ileum Ill-defined sites within respiratory system Intestinal tract NOS Intra-abdominal lymph nodes Intrahepatic bile duct Intrathoracic lymph nodes Islets of Langerhans Isthmus uteri Jejunum Kidney NOS Labium majus Labium minus Lacrimal gland Laryngeal cartilage Larynx NOS Lateral floor of mouth Lateral wall of bladder Lateral wall of nasopharynx Lateral wall of oropharynx Lesser curvature of stomach NOS Lingual tonsil Lip NOS Liver Long bones of lower limb and associated joints Long bones of upper limb scapula and associated joints Lower gum Lower limb NOS Lower lobe lung Lower third of esophagus Lower-inner quadrant of breast Lower-outer quadrant of breast Lung NOS Lymph node NOS Lymph nodes of axilla or arm Lymph nodes of head face and neck Lymph nodes of inguinal region or leg Lymph nodes of multiple regions Main bronchus Major salivary gland NOS Male genital organs NOS Mandible Maxillary sinus Meckel diverticulum Mediastinum NOS Medulla of adrenal gland Meninges NOS Middle ear Middle lobe lung Middle third of esophagus Mouth NOS Mucosa of lip NOS Mucosa of lower lip Mucosa of upper lip Myometrium Nasal cavity Nasopharynx NOS Nervous system NOS Nipple Occipital lobe Olfactory nerve Optic nerve Orbit NOS Oropharynx NOS Other ill-defined sites Other specified parts of female genital organs Other specified parts of male genital organs Other specified parts of pancreas Ovary Overlapping lesion of accessory sinuses Overlapping lesion of bladder Overlapping lesion of bones joints and articular cartilage Overlapping lesion of bones joints and articular cartilage of limbs Overlapping lesion of brain Overlapping lesion of brain and central nervous system Overlapping lesion of breast Overlapping lesion of cervix uteri Overlapping lesion of colon Overlapping lesion of connective subcutaneous and other soft tissues Overlapping lesion of corpus uteri Overlapping lesion of digestive system Overlapping lesion of endocrine glands and related structures Overlapping lesion of esophagus Overlapping lesion of eye and adnexa Overlapping lesion of female genital organs Overlapping lesion of floor of mouth Overlapping lesion of heart mediastinum and pleura Overlapping lesion of hypopharynx Overlapping lesion of ill-defined sites Overlapping lesion of larynx Overlapping lesion of lip Overlapping lesion of lip oral cavity and pharynx Overlapping lesion of lung Overlapping lesion of major salivary glands Overlapping lesion of male genital organs Overlapping lesion of nasopharynx Overlapping lesion of other and unspecified parts of mouth Overlapping lesion of palate Overlapping lesion of pancreas Overlapping lesion of penis Overlapping lesion of peripheral nerves and autonomic nervous system Overlapping lesion of rectum anus and anal canal Overlapping lesion of respiratory system and intrathoracic organs Overlapping lesion of retroperitoneum and peritoneum Overlapping lesion of skin Overlapping lesion of small intestine Overlapping lesion of stomach Overlapping lesion of tongue Overlapping lesion of tonsil Overlapping lesion of urinary organs Overlapping lesion of vulva Overlapping lesions of oropharynx Palate NOS Pancreas NOS Pancreatic duct Parametrium Paraspinal Parathyroid gland Paraurethral gland Parietal lobe Parotid gland Pelvic bones sacrum coccyx and associated joints Pelvic lymph nodes Pelvis NOS Penis NOS Peripheral nerves and autonomic nervous system of abdomen Peripheral nerves and autonomic nervous system of head face and neck Peripheral nerves and autonomic nervous system of lower limb and hip Peripheral nerves and autonomic nervous system of pelvis Peripheral nerves and autonomic nervous system of thorax Peripheral nerves and autonomic nervous system of trunk NOS Peripheral nerves and autonomic nervous system of upper limb and shoulder Peritoneum NOS Pharynx NOS Pineal gland Pituitary gland Placenta Pleura NOS Postcricoid region Posterior mediastinum Posterior wall of bladder Posterior wall of hypopharynx Posterior wall of nasopharynx Posterior wall of oropharynx Prepuce Prostate gland Pylorus Pyriform sinus Rectosigmoid junction Rectum NOS Renal pelvis Reticuloendothelial system NOS Retina Retromolar area Retroperitoneum Rib sternum clavicle and associated joints Round ligament Scrotum NOS Short bones of lower limb and associated joints Short bones of upper limb and associated joints Sigmoid colon Skin of lip NOS skin of lower limb and hip Skin of other and unspecified parts of face Skin of scalp and neck Skin of trunk skin of upper limb and shoulder skin NOS Small intestine NOS Soft palate NOS Specified parts of peritoneum Spermatic cord Sphenoid sinus Spinal cord Spinal meninges Spleen Splenic flexure of colon Stomach NOS Subglottis Sublingual gland Submandibular gland Superior wall of nasopharynx Supraglottis Tail of pancreas Temporal lobe Testis NOS Thoracic esophagus Thorax NOS Thymus Thyroid gland Tongue NOS Tonsil NOS Tonsillar fossa Tonsillar pillar Trachea Transverse colon Trigone of bladder Undescended testis unknown primary site Upper gum Upper limb NOS Upper lobe lung Upper respiratory tract NOS Upper third of esophagus Upper-inner quadrant of breast Upper-outer quadrant of breast Urachus Ureter Ureteric orifice Urethra Urinary system NOS Uterine adnexa Uterus NOS Uvula Vagina NOS Vallecula Ventral surface of tongue NOS Ventricle NOS Vertebral column Vestibule of mouth Vulva NOS Waldeyer ring Biliary tract NOS Cheek mucosa Clitoris Overlapping lesion of biliary tract unknown Not Reported
Tissue or Organ of Origin	Diagnosis	The text term used to describe the anatomic site of origin, of the patient's malignant disease, as described by the World Health Organization's (WHO) International Classification of Diseases for Oncology (ICD-O).	True		String	Abdomen NOS Abdominal esophagus Accessory sinus NOS Acoustic nerve Adrenal gland NOS Ampulla of Vater Anal canal Anterior 2/3 of tongue NOS Anterior floor of mouth Anterior mediastinum Anterior surface of epiglottis Anterior wall of bladder Anterior wall of nasopharynx Anus NOS Aortic body and other paraganglia Appendix Ascending colon Autonomic nervous system NOS Axillary tail of breast Base of tongue NOS Bladder neck Bladder NOS Blood Body of pancreas Body of penis Body of stomach Bone marrow Bone of limb NOS Bone NOS Bones of skull and face and associated joints Border of tongue Brain stem Brain NOS Branchial cleft Breast NOS Broad ligament Cardia NOS Carotid body Cauda equina Cecum Central portion of breast Cerebellum NOS Cerebral meninges Cerebrum Cervical esophagus Cervix uteri Choroid Ciliary body Cloacogenic zone Colon NOS Commissure of lip Conjunctiva Connective subcutaneous and other soft tissues of abdomen Connective subcutaneous and other soft tissues of head face and neck Connective subcutaneous and other soft tissues of lower limb and hip Connective subcutaneous and other soft tissues of pelvis Connective subcutaneous and other soft tissues of thorax Connective subcutaneous and other soft tissues of trunk NOS Connective subcutaneous and other soft tissues of upper limb and shoulder Connective subcutaneous and other soft tissues NOS Cornea NOS Corpus uteri Cortex of adrenal gland Cranial nerve NOS Craniopharyngeal duct Descended testis Descending colon Dome of bladder Dorsal surface of tongue NOS Duodenum Endocervix Endocrine gland NOS Endometrium Epididymis Esophagus NOS Ethmoid sinus Exocervix External ear External lip NOS External lower lip External upper lip Extrahepatic bile duct Eye NOS Eyelid Fallopian tube Female genital tract NOS Floor of mouth NOS Frontal lobe Frontal sinus Fundus of stomach Fundus uteri Gallbladder Gastric antrum Gastrointestinal tract NOS Glans penis Glottis Greater curvature of stomach NOS Gum NOS Hard palate Head of pancreas Head face or neck NOS Heart Hematopoietic system NOS Hepatic flexure of colon Hypopharyngeal aspect of aryepiglottic fold Hypopharynx NOS Ileum Ill-defined sites within respiratory system Intestinal tract NOS Intra-abdominal lymph nodes Intrahepatic bile duct Intrathoracic lymph nodes Islets of Langerhans Isthmus uteri Jejunum Kidney NOS Labium majus Labium minus Lacrimal gland Laryngeal cartilage Larynx NOS Lateral floor of mouth Lateral wall of bladder Lateral wall of nasopharynx Lateral wall of oropharynx Lesser curvature of stomach NOS Lingual tonsil Lip NOS Liver Long bones of lower limb and associated joints Long bones of upper limb scapula and associated joints Lower gum Lower limb NOS Lower lobe lung Lower third of esophagus Lower-inner quadrant of breast Lower-outer quadrant of breast Lung NOS Lymph node NOS Lymph nodes of axilla or arm Lymph nodes of head face and neck Lymph nodes of inguinal region or leg Lymph nodes of multiple regions Main bronchus Major salivary gland NOS Male genital organs NOS Mandible Maxillary sinus Meckel diverticulum Mediastinum NOS Medulla of adrenal gland Meninges NOS Middle ear Middle lobe lung Middle third of esophagus Mouth NOS Mucosa of lip NOS Mucosa of lower lip Mucosa of upper lip Myometrium Nasal cavity Nasopharynx NOS Nervous system NOS Nipple Occipital lobe Olfactory nerve Optic nerve Orbit NOS Oropharynx NOS Other ill-defined sites Other specified parts of female genital organs Other specified parts of male genital organs Other specified parts of pancreas Ovary Overlapping lesion of accessory sinuses Overlapping lesion of bladder Overlapping lesion of bones joints and articular cartilage Overlapping lesion of bones joints and articular cartilage of limbs Overlapping lesion of brain Overlapping lesion of brain and central nervous system Overlapping lesion of breast Overlapping lesion of cervix uteri Overlapping lesion of colon Overlapping lesion of connective subcutaneous and other soft tissues Overlapping lesion of corpus uteri Overlapping lesion of digestive system Overlapping lesion of endocrine glands and related structures Overlapping lesion of esophagus Overlapping lesion of eye and adnexa Overlapping lesion of female genital organs Overlapping lesion of floor of mouth Overlapping lesion of heart mediastinum and pleura Overlapping lesion of hypopharynx Overlapping lesion of ill-defined sites Overlapping lesion of larynx Overlapping lesion of lip Overlapping lesion of lip oral cavity and pharynx Overlapping lesion of lung Overlapping lesion of major salivary glands Overlapping lesion of male genital organs Overlapping lesion of nasopharynx Overlapping lesion of other and unspecified parts of mouth Overlapping lesion of palate Overlapping lesion of pancreas Overlapping lesion of penis Overlapping lesion of peripheral nerves and autonomic nervous system Overlapping lesion of rectum anus and anal canal Overlapping lesion of respiratory system and intrathoracic organs Overlapping lesion of retroperitoneum and peritoneum Overlapping lesion of skin Overlapping lesion of small intestine Overlapping lesion of stomach Overlapping lesion of tongue Overlapping lesion of tonsil Overlapping lesion of urinary organs Overlapping lesion of vulva Overlapping lesions of oropharynx Palate NOS Pancreas NOS Pancreatic duct Parametrium Paraspinal Parathyroid gland Paraurethral gland Parietal lobe Parotid gland Pelvic bones sacrum coccyx and associated joints Pelvic lymph nodes Pelvis NOS Penis NOS Peripheral nerves and autonomic nervous system of abdomen Peripheral nerves and autonomic nervous system of head face and neck Peripheral nerves and autonomic nervous system of lower limb and hip Peripheral nerves and autonomic nervous system of pelvis Peripheral nerves and autonomic nervous system of thorax Peripheral nerves and autonomic nervous system of trunk NOS Peripheral nerves and autonomic nervous system of upper limb and shoulder Peritoneum NOS Pharynx NOS Pineal gland Pituitary gland Placenta Pleura NOS Postcricoid region Posterior mediastinum Posterior wall of bladder Posterior wall of hypopharynx Posterior wall of nasopharynx Posterior wall of oropharynx Prepuce Prostate gland Pylorus Pyriform sinus Rectosigmoid junction Rectum NOS Renal pelvis Reticuloendothelial system NOS Retina Retromolar area Retroperitoneum Rib sternum clavicle and associated joints Round ligament Scrotum NOS Short bones of lower limb and associated joints Short bones of upper limb and associated joints Sigmoid colon Skin of lip NOS skin of lower limb and hip Skin of other and unspecified parts of face Skin of scalp and neck Skin of trunk skin of upper limb and shoulder skin NOS Small intestine NOS Soft palate NOS Specified parts of peritoneum Spermatic cord Sphenoid sinus Spinal cord Spinal meninges Spleen Splenic flexure of colon Stomach NOS Subglottis Sublingual gland Submandibular gland Superior wall of nasopharynx Supraglottis Tail of pancreas Temporal lobe Testis NOS Thoracic esophagus Thorax NOS Thymus Thyroid gland Tongue NOS Tonsil NOS Tonsillar fossa Tonsillar pillar Trachea Transverse colon Trigone of bladder Undescended testis unknown primary site Upper gum Upper limb NOS Upper lobe lung Upper respiratory tract NOS Upper third of esophagus Upper-inner quadrant of breast Upper-outer quadrant of breast Urachus Ureter Ureteric orifice Urethra Urinary system NOS Uterine adnexa Uterus NOS Uvula Vagina NOS Vallecula Ventral surface of tongue NOS Ventricle NOS Vertebral column Vestibule of mouth Vulva NOS Waldeyer ring Biliary tract NOS Cheek mucosa Clitoris Overlapping lesion of biliary tract unknown Not Reported
Morphology	Diagnosis	The third edition of the International Classification of Diseases for Oncology, published in 2000 used principally in tumor and cancer registries for coding the site (topography) and the histology (morphology) of neoplasms. The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs. In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains. A system of numbered categories for representation of data.	True		String	
Tumor Grade	Diagnosis	Numeric value to express the degree of abnormality of cancer cells, a measure of differentiation and aggressiveness.	False		String	G1 G2 G3 G4 GX GB High Grade Intermediate Grade Low Grade unknown Not Reported Not Applicable
Progression or Recurrence	Diagnosis,Follow Up	Yes/No/unknown indicator to identify whether a patient has had a new tumor event after initial treatment.	True		String	Yes - Progression or Recurrence no unknown Not Reported
Last Known Disease Status	Diagnosis	Text term that describes the last known state or condition of an individual's neoplasm.	True		String	Distant met recurrence/progression Loco-regional recurrence/progression Biochemical evidence of disease without structural correlate Tumor free unknown tumor status With tumor Not Reported Not Allowed To Collect Not Applicable
Days to Last Follow up	Diagnosis	Time interval from the date of last follow up to the date of initial pathologic diagnosis, represented as a calculated number of days. If not applicable please enter 'Not Applicable'	True		String	
Days to Last Known Disease Status	Diagnosis	Time interval from the date of last follow up to the date of initial pathologic diagnosis, represented as a calculated number of days. If not applicable please enter 'Not Applicable'	True		String	
Method of Diagnosis	Diagnosis	Text term used to describe the method used to confirm the patients malignant diagnosis.	False		String	Autopsy Biopsy Blood Draw Bone Marrow Aspirate Core Biopsy Cytology Cystoscopy Debulking Diagnostic Imaging Dilation and Curettage Procedure Enucleation Excisional Biopsy Fine Needle Aspiration Incisional Biopsy Laparoscopy Laparotomy Other Pap Smear Physical Exam Pathologic Review Surgical Resection Thoracentesis Ultrasound Guided Biopsy unknown Not Reported
Prior Malignancy	Diagnosis	The yes/no/unknown indicator used to describe the patient's history of prior cancer diagnosis.	False		String	yes no unknown Not Reported Not Allowed To Collect
Prior Treatment	Diagnosis	A yes/no/unknown/not applicable indicator related to the administration of therapeutic agents received before the body specimen was collected.	False		String	yes no unknown Not Reported Not Allowed To Collect
Metastasis at Diagnosis	Diagnosis	The text term used to describe the extent of metastatic disease present at diagnosis.	False		String	Distant Metastasis Metastasis NOS No Metastasis Regional Metastasis unknown Not Reported
Metastasis at Diagnosis Site	Diagnosis	Text term to identify an anatomic site in which metastatic disease involvement is found.	False		String	Abdomen Adrenal Gland Ascites Bone Bone Marrow Brain Cerebrospinal Fluid Central Nervous System Colon Distant Nodes Distant Organ Groin Kidney Liver Lung Lymph Node Axillary Inguinal Lymph Node NOS Mediastinum Omentum Ovary Pelvis Peritoneal Cavity Peritoneum Pleura Scalp Skin Small Intestine Soft Tissue Spinal Cord unknown Not Reported
First Symptom Prior to Diagnosis	Diagnosis	Text term used to describe the patient's first symptom experienced prior to diagnosis and thought to be related to the disease.	False		String	Altered Mental Status Headaches Motor or Movement Changes Seizures Sensory Changes Visual Changes unknown Not Reported
Days to Diagnosis	Diagnosis	Number of days between the date used for index and the date the patient was diagnosed with the malignant disease. If not applicable please enter 'Not Applicable'	False		String	
Percent Tumor Invasion	Diagnosis	The percentage of tumor cells spread locally in a malignant neoplasm through infiltration or destruction of adjacent tissue.	False		String	
Residual Disease	Diagnosis,Therapy	Text terms to describe the status of a tissue margin following surgical resection.	False		String	R0 R1 R2 RX unknown Not Reported
Synchronous Malignancy	Diagnosis	A yes/no/unknown indicator used to describe whether the patient had an additional malignant diagnosis at the same time the tumor used for sequencing was diagnosed. If both tumors were sequenced, both tumors would have synchronous malignancies.	False		String	yes no unknown Not Reported
Tumor Confined to Organ of Origin	Diagnosis	The yes/no/unknown indicator used to describe whether the tumor is confined to the organ where it originated and did not spread to a proximal or distant location within the body.	False		String	yes no unknown Not Reported
Tumor Focality	Diagnosis	The text term used to describe whether the patient's disease originated in a single location or multiple locations.	False		String	Multifocal Unifocal unknown Not Reported
Tumor Largest Dimension Diameter	Diagnosis	Numeric value used to describe the maximum diameter or dimension of the primary tumor, measured in centimeters.	False		String	
Gross Tumor Weight	Diagnosis	Numeric value used to describe the gross pathologic tumor weight, measured in grams.	False		String	
Breslow Thickness	Diagnosis	The number that describes the distance, in millimeters, between the upper layer of the epidermis and the deepest point of tumor penetration.	False		String	
Vascular Invasion Present	Diagnosis	The yes/no indicator to ask if large vessel or venous invasion was detected by surgery or presence in a tumor specimen.	False		String	Yes - Vascular Invasion Present no unknown Not Reported Not Allowed To Collect
Vascular Invasion Type	Diagnosis	Text term that represents the type of vascular tumor invasion.	False		String	Extramural Intramural Macro Micro No Vascular Invasion unknown Not Reported
Anaplasia Present	Diagnosis	Yes/no/unknown/Not Reported indicator used to describe whether anaplasia was present at the time of diagnosis.	False		String	Yes - Anaplasia Present no unknown Not Reported
Anaplasia Present Type	Diagnosis	The text term used to describe the morphologic findings indicating the presence of a malignant cellular infiltrate characterized by the presence of large pleomorphic cells, necrosis, and high mitotic activity in a tissue sample.	False		String	Absent Diffuse Equivocal Focal Present Sclerosis unknown Not Reported
Laterality	Diagnosis	For tumors in paired organs, designates the side on which the cancer originates.	False		String	Bilateral Left Midline Right Unilateral unknown Not Reported
Perineural Invasion Present	Diagnosis	A yes/no indicator to ask if perineural invasion or infiltration of tumor or cancer is present.	False		String	yes no unknown Not Reported
Lymphatic Invasion Present	Diagnosis	A yes/no indicator to ask if small or thin-walled vessel invasion is present, indicating lymphatic involvement	False		String	yes no unknown Not Reported
Lymph Nodes Positive	Diagnosis	The number of lymph nodes involved with disease as determined by pathologic examination.	False		String	
Lymph Nodes Tested	Diagnosis	The number of lymph nodes tested to determine whether lymph nodes were involved with disease as determined by a pathologic examination.	False		String	
Peritoneal Fluid Cytological Status	Diagnosis	The text term used to describe the malignant status of the peritoneal fluid determined by cytologic testing.	False		String	Atypical Malignant Non-Malignant Unsatisfactory unknown Not Reported
Classification of Tumor	Diagnosis	Text that describes the kind of disease present in the tumor specimen as related to a specific timepoint.	False		String	Primary Metastasis Recurrence Other unknown Not Reported Not Allowed To Collect
Best Overall Response	Diagnosis	The best improvement achieved throughout the entire course of protocol treatment.	False		String	AJ-Adjuvant Therapy CPD-Clinical Progression CR-Complete Response CRU-Complete Response Unconfirmed DU-Disease Unchanged IMR-Immunoresponse IPD-Immunoprogression MR-Minimal/Marginal Response MX-Mixed Response Non-CR/Non-PD-Non-CR/Non-PD NPB-No Palliative Benefit NR-No Response PA-Palliative Therapy PB-Palliative Benefit PD-Progressive Disease PPD-Pseudoprogression PR-Partial Response PSR-Pseudoresponse RD-Responsive Disease RP-Response RPD-Radiographic Progressive Disease sCR-Stringent Complete Response SD-Stable Disease SPD-Surgical Progression TE-Too Early VGPR-Very Good Partial Response
Mitotic Count	Diagnosis	The number of mitoses identified under the microscope in tumors. The method of counting varies, according to the specific tumor examined. Usually, the mitotic count is determined based on the number of mitoses per high power field (40X) or 10 high power fields.	False		String	
AJCC Clinical M	Diagnosis	Extent of the distant metastasis for the cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.	False		String	M0 M1 M1a M1b M1c MX cM0 (i+) unknown Not Reported
AJCC Clinical N	Diagnosis	Extent of the regional lymph node involvement for the cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.	False		String	N0 N0 (i+) N0 (i-) N0 (mol+) N0 (mol-) N1 N1a N1b N1bI N1bII N1bIII N1bIV N1c N1mi N2 N2a N2b N2c N3 N3a N3b N3c N4 NX unknown Not Reported
AJCC Clinical Stage	Diagnosis	Stage group determined from clinical information on the tumor (T), regional node (N) and metastases (M) and by grouping cases with similar prognosis for cancer.	False		String	Stage 0 Stage 0a Stage 0is Stage I Stage IA Stage IA1 Stage IA2 Stage IB Stage IB1 Stage IB2 Stage IC Stage II Stage IIA Stage IIA1 Stage IIA2 Stage IIB Stage IIC Stage IIC1 Stage III Stage IIIA Stage IIIB Stage IIIC Stage IIIC1 Stage IIIC2 Stage IS Stage IV Stage IVA Stage IVB Stage IVC Stage Tis Stage X unknown Not Reported
AJCC Clinical T	Diagnosis	Extent of the primary cancer based on evidence obtained from clinical assessment parameters determined prior to treatment.	False		String	T0 T1 T1a T1a1 T1a2 T1b T1b1 T1b2 T1c T1mi T2 T2a T2a1 T2a2 T2b T2c T2d T3 T3a T3b T3c T3d T4 T4a T4b T4c T4d T4e TX Ta Tis Tis (DCIS) Tis (LCIS) Tis (Paget's) unknown Not Reported
AJCC Pathologic M	Diagnosis	Code to represent the defined absence or presence of distant spread or metastases (M) to locations via vascular channels or lymphatics beyond the regional lymph nodes, using criteria established by the American Joint Committee on Cancer (AJCC).	False		String	M0 M1 M1a M1b M1c MX cM0 (i+) unknown Not Reported
AJCC Pathologic N	Diagnosis	The codes that represent the stage of cancer based on the nodes present (N stage) according to criteria based on multiple editions of the AJCC's Cancer Staging Manual.	False		String	N0 N0 (i+) N0 (i-) N0 (mol+) N0 (mol-) N1 N1a N1b N1bI N1bII N1bIII N1bIV N1c N1mi N2 N2a N2b N2c N3 N3a N3b N3c N4 NX unknown Not Reported
AJCC Pathologic Stage	Diagnosis	The extent of a cancer, especially whether the disease has spread from the original site to other parts of the body based on AJCC staging criteria.	False		String	Stage 0 Stage 0a Stage 0is Stage I Stage IA Stage IA1 Stage IA2 Stage IB Stage IB1 Stage IB2 Stage IC Stage II Stage IIA Stage IIA1 Stage IIA2 Stage IIB Stage IIC Stage IIC1 Stage III Stage IIIA Stage IIIB Stage IIIC Stage IIIC1 Stage IIIC2 Stage IS Stage IV Stage IVA Stage IVB Stage IVC Stage Tis Stage X unknown Not Reported
AJCC Pathologic T	Diagnosis	Code of pathological T (primary tumor) to define the size or contiguous extension of the primary tumor (T), using staging criteria from the American Joint Committee on Cancer (AJCC).	False		String	T0 T1 T1a T1a1 T1a2 T1b T1b1 T1b2 T1c T1mi T2 T2a T2a1 T2a2 T2b T2c T2d T3 T3a T3b T3c T3d T4 T4a T4b T4c T4d T4e TX Ta Tis Tis (DCIS) Tis (LCIS) Tis (Paget's) unknown Not Reported
AJCC Staging System Edition	Diagnosis	The text term used to describe the version or edition of the American Joint Committee on Cancer Staging Handbooks, a publication by the group formed for the purpose of developing a system of staging for cancer that is acceptable to the American medical profession and is compatible with other accepted classifications.	False		String	1st 2nd 3rd 4th 5th 6th 7th 8th unknown Not Reported
Cog Neuroblastoma Risk Group	Diagnosis	Text term that represents the categorization of patients on the basis of prognostic factors per a system developed by Children's Oncology Group (COG). Risk level is used to assign treatment intensity.	False		String	High Risk Intermediate Risk Low Risk unknown Not Reported
Cog Rhabdomyosarcoma Risk Group	Diagnosis	Text term used to describe the classification of rhabdomyosarcoma, as defined by the Children's Oncology Group (COG).	False		String	High Risk Intermediate Risk Low Risk unknown Not Reported
Gleason Grade Group	Diagnosis	The text term used to describe the overall grouping of grades defined by the Gleason grading classification, which is used to determine the aggressiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.	False		String	Group 1 Group 2 Group 3 Group 4 Group 5
Gleason Grade Tertiary	Diagnosis	The text term used to describe the tertiary pattern as described by the Gleason Grading System.	False		String	Pattern 4 Pattern 5
Gleason Patterns Percent	Diagnosis	Numeric value that represents the percentage of Patterns 4 and 5, which is used when the Gleason score is greater than 7 to predict prognosis.	False		String	
Greatest Tumor Dimension	Diagnosis	Numeric value that represents the measurement of the widest portion of the tumor in centimeters.	False		String	
IGCCCG Stage	Diagnosis	The text term used to describe the International Germ Cell Cancer Collaborative Group (IGCCCG), a grouping used to further classify metastatic testicular tumors.	False		String	Good Prognosis Intermediate Prognosis Poor Prognosis unknown Not Reported
INPC Grade	Diagnosis	Text term used to describe the classification of neuroblastic differentiation within neuroblastoma tumors, as defined by the International Neuroblastoma Pathology Classification (INPC).	False		String	Differentiating Poorly Differentiated Undifferentiated unknown Not Reported
INPC Histologic Group	Diagnosis	The text term used to describe the classification of neuroblastomas distinguishing between favorable and unfavorable histologic groups. The histologic score, defined by the International Neuroblastoma Pathology Classification (INPC), is based on age, mitosis-karyorrhexis index (MKI), stromal content and degree of tumor cell differentiation.	False		String	Favorable Unfavorable unknown Not Reported
INRG Stage	Diagnosis	The text term used to describe the staging classification of neuroblastic tumors, as defined by the International Neuroblastoma Risk Group (INRG).	False		String	L1 L2 M Ms unknown Not Reported
INSS Stage	Diagnosis	Text term used to describe the staging classification of neuroblastic tumors, as defined by the International Neuroblastoma Staging System (INSS).	False		String	Stage 1 Stage 2A Stage 2B Stage 3 Stage 4 Stage 4S unknown Not Reported
International Prognostic Index	Diagnosis	The text term used to describe the International Prognostic Index, which classifies the prognosis of patients with aggressive non-Hodgkin's lymphoma.	False		String	Low Risk Low-Intermediate Risk High-Intermediate Risk High Risk
IRS Group	Diagnosis	Text term used to describe the classification of rhabdomyosarcoma tumors, as defined by the Intergroup Rhabdomyosarcoma Study (IRS).	False		String	Group I Group Ia Group Ib Group II Group IIa Group IIc Group III Group IIIa Group IIIb Group IV unknown Not Reported
IRS Stage	Diagnosis	The text term used to describe the classification of rhabdomyosarcoma tumors, as defined by the Intergroup Rhabdomyosarcoma Study (IRS).	False		String	1 2 3 4 unknown Not Reported
ISS Stage	Diagnosis	The multiple myeloma disease stage at diagnosis.	False		String	I II III Not Reported unknown
Lymph Node Involved Site	Diagnosis	The text term used to describe the anatomic site of lymph node involvement.	False		String	Axillary Cervical Epitrochlear Femoral Hilar Iliac-common Iliac-external Iliac NOS Inguinal Mediastinal Mesenteric None Occipital Paraaortic Parotid Popliteal Retroperitoneal Splenic Submandibular Supraclavicular unknown Not Reported
Margin Distance	Diagnosis	Numeric value (in centimeters) that represents the distance between the tumor and the surgical margin.	False		String	
Margins Involved Site	Diagnosis	The text term used to describe the anatomic sites that were involved in the survival margins.	False		String	Gerota Fascia Parenchyma Perinephric Fat Renal Renal Capsule Renal Sinus Renal Vein Ureter
Medulloblastoma Molecular Classification	Diagnosis	The text term used to describe the classification of medulloblastoma tumors based on molecular features.	False		String	Not Determined Non-WNT/non-SHH Activated SHH-Activated WNT-Activated unknown Not Reported
Micropapillary Features	Diagnosis	The yes/no/unknown indicator used to describe whether micropapillary features were determined to be present.	False		String	Absent Present unknown Not Reported
Mitosis Karyorrhexis Index	Diagnosis	Text term that represents the component of the International Neuroblastoma Pathology Classification (INPC) for mitosis-karyorrhexis index (MKI).	False		String	High Intermediate Low unknown Not Reported
Non Nodal Regional Disease	Diagnosis	The text term used to describe whether the patient had non-nodal regional disease.	False		String	Absent Indeterminate Present unknown Not Reported
Non Nodal Tumor Deposits	Diagnosis	The yes/no/unknown indicator used to describe the presence of tumor deposits in the pericolic or perirectal fat or in adjacent mesentery away from the leading edge of the tumor.	False		String	yes no unknown Not Reported
Ovarian Specimen Status	Diagnosis	The text term used to describe the physical condition of the involved ovary.	False		String	Ovarian Capsule Intact Ovarian Capsule Ruptured Ovarian Capsule Fragmented unknown Not Reported
Ovarian Surface Involvement	Diagnosis	The text term that describes whether the surface tissue (outer boundary) of the ovary shows evidence of involvement or presence of cancer.	False		String	Absent Present Indeterminate unknown Not Reported
Pregnant at Diagnosis	Diagnosis	The text term used to indicate whether the patient was pregnant at the time they were diagnosed.	False		String	yes no unknown Not Reported
Primary Gleason Grade	Diagnosis	The text term used to describe the primary Gleason score, which describes the pattern of cells making up the largest area of the tumor. The primary and secondary Gleason pattern grades are combined to determine the patient's Gleason grade group, which is used to determine the aggresiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.	False		String	Pattern 1 Pattern 2 Pattern 3 Pattern 4 Pattern 5
Secondary Gleason Grade	Diagnosis	The text term used to describe the secondary Gleason score, which describes the pattern of cells making up the second largest area of the tumor. The primary and secondary Gleason pattern grades are combined to determine the patient's Gleason grade group, which is used to determine the aggresiveness of prostate cancer. Note that this grade describes the entire prostatectomy specimen and is not specific to the sample used for sequencing.	False		String	Pattern 1 Pattern 2 Pattern 3 Pattern 4 Pattern 5
Supratentorial Localization	Diagnosis	Text term to specify the location of the supratentorial tumor.	False		String	Cerebral Cortex Deep Gray Spinal Cord White Matter unknown Not Reported
Tumor Depth	Diagnosis	Numeric value that represents the depth of tumor invasion, measured in millimeters (mm).	False		String	
WHO CNS Grade	Diagnosis	WHO CNS Grade	False		String	Grade I Grade II Grade III Grade IV Grade Not Assigned unknown Not Reported
WHO NTE Grade	Diagnosis	WHO NTE Grade	False		String	G1 G2 G3 GX unknown Not Reported
Sentinel Lymph Node Count	Diagnosis,Clinical Data Tier 2	Numeric count of sentinel lymph nodes.	False		String	
Sentinel Node Positive Assessment Count	Diagnosis,Clinical Data Tier 2	The number or amount of metastatic neoplasms related to the confirmed presence of disease or specific microorganisms during examination of the first rounded mass of lymphatic tissue to which cancer is likely to spread from the primary tumor.	False		String	
Tumor Extranodal Extension Indicator	Diagnosis,Clinical Data Tier 2	The indicator to determine extranodal involvement or extent of the disease.	False		String	Absent Indeterminate NO YES No source documentation Not applicable Not sampled or dissected Present Present - extensive Present - minimal UNKNOWN Unspecified
Satellite Metastasis Present Indicator	Diagnosis,Clinical Data Tier 2	A yes/no indicator to ask if intransit metastases or satellite lesions are present.	False		String	yes no unknown
Other Biopsy Resection Site	Diagnosis,Clinical Data Tier 2	A description of the location on or within the human body where the surgical biopsy/resection procedure was performed (Not covered under HTAN Clinical Data Tier 1)	False		String	
Extent of Tumor Resection	Diagnosis,Clinical Data Tier 2	The degree to which the lesion has been cut out, or resected.	False		String	Gross Total Resection Open Biopsy Subtotal Resection Extensive Subtotal Minor Optimal debulking Other Partial debulking Segmental Suboptimal Suboptimal debulking NTR unknown Not Reported Not Applicable
Mode of Cancer Detection	Diagnosis,Clinical Data Tier 2	Text term used to describe the mode of cancer detection, like standard of care screening or random detection	False		String	Standard of Care Screening Clinical Examination of unrelated cancer symptoms Incidentaloma Interval Cancer Data not available
NCI Atlas Cancer Site	Diagnosis	The primary tumor site used to calculate the incidence rate using the NCI Cancer Atlas, a digital atlas which provides geographical data related to cancer utilizing the Surveillance, Epidemiology, and End Results (SEER) Program cancer incidence rates for 2013 to 2017	False		String	Bladder Brain And Other Nervous System Female Breast In situ Female Breast Cervix Uteri Less Than Age Malignant Childhood Neoplasm Colon And Rectum Esophagus Kidney And Renal Pelvis Leukemia Liver And Bile Duct Lung And Bronchus Cutaneous Melanoma Non-Hodgkin's Lymphoma Oral Cavity And Pharynx Ovary Pancreas Prostate Gland Stomach Thyroid Gland Uterus
Topography Code	Diagnosis	Topography Code, indicating site within the body, based on ICD-O-3.	False		String	C00.0 C00.1 C00.2 C00.3 C00.4 C00.5 C00.6 C00.8 C01.9 C02.0 C02.1 C02.2 C02.3 C02.4 C02.8 C02.9 C03.0 C03.1 C03.9 C04.0 C04.1 C04.8 C04.9 C05.0 C05.1 C05.2 C05.8 C05.9 C06.0 C06.1 C06.2 C06.8 C06.9 C07.9 C08.0 C08.1 C08.8 C08.9 C09.0 C09.1 C09.8 C09.9 C10.0 C10.1 C10.2 C10.3 C10.4 C10.8 C10.9 C11.0 C11.1 C11.2 C11.3 C11.8 C11.9 C12.9 C13.0 C13.1 C13.2 C13.8 C13.9 C14.0 C14.2 C14.8 C15.0 C15.1 C15.2 C15.3 C15.4 C15.5 C15.8 C15.9 C16.0 C16.1 C16.2 C16.3 C16.4 C16.5 C16.6 C16.8 C16.9 C17.0 C17.1 C17.2 C17.3 C17.8 C17.9 C18.0 C18.1 C18.2 C18.3 C18.4 C18.5 C18.6 C18.7 C18.8 C18.9 C19.9 C20.9 C21.0 C21.1 C21.2 C21.8 C22.0 C22.1 C23.9 C24.0 C24.1 C24.8 C24.9 C25.0 C25.1 C25.2 C25.3 C25.4 C25.7 C25.8 C25.9 C26.0 C26.8 C26.9 C30.0 C30.1 C31.0 C31.1 C31.2 C31.3 C31.8 C31.9 C32.0 C32.1 C32.2 C32.3 C32.8 C32.9 C33.9 C34.0 C34.1 C34.2 C34.3 C34.8 C34.9 C37.9 C38.0 C38.1 C38.2 C38.3 C38.4 C38.8 C39.0 C39.8 C39.9 C40.0 C40.1 C40.3 C40.8 C40.9 C41.0 C41.1 C41.2 C41.3 C41.4 C41.8 C41.9 C42.0 C42.1 C42.2 C42.3 C42.4 C44.0 C44.1 C44.2 C44.3 C44.4 C44.5 C44.6 C44.7 C47.0 C47.1 C47.2 C47.3 C47.4 C47.5 C47.6 C47.8 C47.9 C48.0 C48.1 C48.2 C48.8 C49.0 C49.1 C49.2 C49.3 C49.4 C49.5 C49.6 C49.8 C49.9 C50.0 C50.1 C50.2 C50.3 C50.4 C50.5 C50.6 C50.8 C50.9 C51.0 C51.1 C51.2 C51.8 C51.9 C52.9 C53.0 C53.1 C53.8 C53.9 C54.0 C54.1 C54.2 C54.3 C54.8 C54.9 C55.9 C56.9 C57.0 C57.1 C57.2 C57.3 C57.4 C57.7 C57.8 C57.9 C60.0 C60.1 C60.2 C60.8 C60.9 C61.9 C62.0 C62.1 C62.9 C63.0 C63.1 C63.2 C63.7 C63.8 C63.9 C64.9 C65.9 C66.9 C67.0 C67.1 C67.2 C67.4 C67.6 C67.7 C67.8 C67.9 C68.0 C68.1 C68.8 C68.9 C69.0 C69.1 C69.2 C69.3 C69.4 C69.5 C69.6 C69.8 C69.9 C70.0 C70.1 C70.9 C71.0 C71.1 C71.2 C71.3 C71.4 C71.5 C71.6 C71.7 C71.8 C71.9 C72.0 C72.1 C72.2 C72.3 C72.4 C72.5 C72.8 C72.9 C73.9 C74.0 C74.1 C74.9 C75.0 C75.1 C75.2 C75.3 C75.4 C75.5 C75.8 C75.9 C76.0 C76.1 C76.2 C76.3 C76.4 C76.5 C76.7 C76.8 C77.0 C77.1 C77.2 C77.3 C77.4 C77.5 C77.8 C77.9 C80.9 unknown Not Reported
Additional Topography	Diagnosis	Topography not included in the ICD-O-3 Topography codes.	False		String	skin of scalp skin of eye lid skin of nose skin of lip skin of ear skin of neck skin of other parts of face skin of chest skin of back skin of abdomen Skin of trunk skin of breast skin of upper limb and shoulder skin of palm skin of lower limb and hip skin of sole skin of penis skin of scrotum skin of vulva skin NOS Hilar Airway Peri-tumoral Airway Not Reported
Days to Progression	Diagnosis	Number of days between the date used for index and the date the patient's disease progressed. If not applicable please enter 'Not Applicable'	False	Progression or Recurrence is "Yes - Progression or Recurrence"	String	
Days to Progression Free	Diagnosis	Number of days between the date used for index and the date the patient's disease was formally confirmed as progression-free. If not applicable please enter 'Not Applicable'	False	Progression or Recurrence is "Yes - Progression or Recurrence"	String	
Yes - Progression or Recurrence	Diagnosis	The patient has had a new tumor event after initial treatment	False		String	
Progression or Recurrence Type	Diagnosis	The text term used to describe the type of progressive or recurrent disease or relapsed disease.	False	Progression or Recurrence is "Yes - Progression or Recurrence"	String	Biochemical Distant Local Regional unknown Not Reported
Yes - Anaplasia Present	Diagnosis	Indicates anaplasia is present	False		String	
Yes - Vascular Invasion Present	Diagnosis	Indicates venous invasion was detected by surgery or presence in a tumor specimen	False		String	
Start Days from Index	Exposure,Molecular Test,Clinical Data Tier 2,Acute Lymphoblastic Leukemia Tier 3,Breast Cancer Tier 3,Colorectal Cancer Tier 3,Lung Cancer Tier 3,Melanoma Tier 3,Ovarian Cancer Tier 3,Pancreatic Cancer Tier 3,Prostate Cancer Tier 3,Sarcoma Tier 3	Number of days from the date of birth (index date) to the date of an event (e.g. exposure to environmental factor, treatment start, etc.). If not applicable please enter 'Not Applicable'	True		String	
Smoking Exposure	Exposure	Indicate if individual has smoking exposure	True		String	Yes - Smoking Exposure No - Smoking Exposure Not Reported
Alcohol Exposure	Exposure	Indicate if individual has alcohol exposure	True		String	Yes - Alcohol Exposure No - Alcohol Exposure Not Reported
Asbestos Exposure	Exposure	The yes/no/unknown indicator used to describe whether the patient was exposed to asbestos.	False		String	yes no unknown Not Reported
Coal Dust Exposure	Exposure	The yes/no/unknown indicator used to describe whether a patient was exposed to fine powder derived by the crushing of coal.	False		String	yes no unknown
Environmental Tobacco Smoke Exposure	Exposure	The yes/no/unknown indicator used to describe whether a patient was exposed to smoke that is emitted from burning tobacco, including cigarettes, pipes, and cigars. This includes tobacco smoke exhaled by smokers.	False		String	yes no unknown
Radon Exposure	Exposure	The yes/no/unknown indicator used to describe whether the patient was exposed to radon.	False		String	yes no unknown Not Reported
Respirable Crystalline Silica Exposure	Exposure	The yes/no/unknown indicator used to describe whether a patient was exposured to respirable crystalline silica, a widespread, naturally occurring, crystalline metal oxide that consists of different forms including quartz, cristobalite, tridymite, tripoli, ganister, chert and novaculite.	False		String	yes no unknown
COVID19 Occurrence Indicator	Exposure,Clinical Data Tier 2	The indicator that describes whether or not a COVID-19 infectious disorder occurred.	False		String	yes no unknown Not Applicable Not Done
COVID19 Current Status	Exposure,Clinical Data Tier 2	The patient's current COVID-19 status of sign or symptom events or interventions	False		String	Patient currently has symptoms Patient had symptoms but now is fully recovered Patient never had any symptoms of COVID-19 Status unknown due to general COVID-19 related travel restrictions Status unknown due to lack of disease/tumor assessment due to COVID-19 diagnosis Status unknown due to other reasons
COVID19 Positive Lab Test Indicator	Exposure,Clinical Data Tier 2	The indicator that describes whether or not there was a COVID-19 positive test result.	False		String	yes no unknown Not Applicable Not Done
COVID19 Antibody Testing	Exposure,Clinical Data Tier 2	Text term that demonstrates the test results of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies to the SARS-CoV-2 virus in subject serum samples.	False		String	SARS-CoV-2 IgM antibody positive SARS-CoV-2 IgG antibody positive SARS-CoV-2 IgG/IgM antibody positive SARS-CoV-2 IgM antibody negative SARS-CoV-2 IgG antibody negative SARS-CoV-2 IgG/IgM antibody negative unknown Not Applicable Not Done
COVID19 Complications Severity	Exposure,Clinical Data Tier 2	Text term that retrospectively indicates the worst complications during COVID-19 infectious disorder in the patient.	False		String	Cardiac complications Pulmonary complications Systemic complications Other Not Applicable unknown
COVID19 Cancer Treatment Followup	Exposure,Clinical Data Tier 2	Indicator that describes if cancer treatment was modified for the patient due to COVID-19 infectious disorder	False		String	yes no unknown Not Applicable
Ecig vape use	Exposure,Clinical Data Tier 2	Use of non-traditional cigarette nicotine delivery device (electronic cigarette, ENDS - electronic nicotine delivery system)	False		String	Current Former Never unknown
Ecig vape 30 day use num	Exposure,Clinical Data Tier 2	Number of days e-cigarettes or vaping device was used in the last 30 days	False		String	
Ecig vape times per day	Exposure,Clinical Data Tier 2	e-cig frequency of use (times per day—one “time” consists of around 15 puffs or lasts around 10 minutes)	False		String	
Type of smoke exposure cumulative years	Exposure,Clinical Data Tier 2	The number of cumulative years of the patient's specific type of smoke exposure	False		String	
Chewing tobacco daily use count	Exposure,Clinical Data Tier 2	The quantity of daily use of tobacco, in the form of a plug, usually flavored, for chewing rather than smoking.	False		String	
Second hand smoke exposure years	Exposure,Clinical Data Tier 2	The number of cumulative years of the patient's exposure to second-hand cigarette smoke	False		String	
Pack Years Smoked	Exposure	Numeric computed value to represent lifetime tobacco exposure defined as number of cigarettes smoked per day x number of years smoked divided by 20.	True	Smoking Exposure is "Yes - Smoking Exposure"	String	
Years Smoked	Exposure	Numeric value (or unknown) to represent the number of years a person has been smoking.	True	Smoking Exposure is "Yes - Smoking Exposure"	String	
Yes - Smoking Exposure	Exposure	Individual has been exposed to smoke; requires additional metadata	False		String	
Cigarettes per Day	Exposure	The average number of cigarettes smoked per day.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	
Smoking Frequency	Exposure	The text term used to generally decribe how often the patient smokes.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Every day Some days unknown
Type of Smoke Exposure	Exposure	The text term used to describe the patient's specific type of smoke exposure.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Accidental building fire smoke Accidental grass fire smoke Accidental fire smoke NOS Accidental forest fire smoke Accidental vehicle fire smoke Aircraft smoke Burning tree smoke Coal smoke NOS Cooking related smoke NOS Electronic cigarette smoke NOS Electrical fire smoke Environmental tobacco smoke Factory smokestack smoke Field burning smoke Fire smoke NOS Furnace or boiler smoke Gas burning smoke propane Grease fire smoke Grilling smoke Hashish smoke Indoor coal burning stove or fireplace smoke Indoor stove or fireplace smoke NOS Indoor wood burning stove or fireplace smoke Machine smoke Marijuana smoke No Smoke Exposure Oil burning smoke Kerosene Oil burning smoke NOS Recreational fire smoke Smoke exposure NOS Smokehouse smoke Tobacco smoke cigar Tobacco smoke cigarettes Tobacco smoke pipe unknown Volcanic smoke Waste burning smoke Wood burning smoke factory Wood burning smoke NOS Workrelated smoke artificial smoke machines Workrelated smoke fire fighting Workrelated smoke foundry Workrelated smoke generators Workrelated smoke military Workrelated smoke NOS Workrelated smoke paint baking Workrelated smoke plastics factory Workrelated smoke plumbing Workrelated smoke soldering/welding
Time between Waking and First Smoke	Exposure	The text term used to describe the approximate amount of time elapsed between the time the patient wakes up in the morning to the time they smoke their first cigarette.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Within 5 Minutes 6-30 Minutes 31-60 Minutes After 60 Minutes unknown
Tobacco Smoking Onset Year	Exposure	The year in which the participant began smoking.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	
Tobacco Smoking Quit Year	Exposure	The year in which the participant quit smoking.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	
Tobacco Smoking Status	Exposure	Category describing current smoking status and smoking history as self-reported by a patient	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Lifelong Non-Smoker Current Smoker Current Reformed Smoker for > 15 yrs Current Reformed Smoker for < or = 15 yrs Current Reformed Smoker Duration Not Specified Smoking history not documented unknown Not Reported
Type of Tobacco Used	Exposure	The text term used to describe the specific type of tobacco used by the patient.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Cigarettes Cigar Electronic Cigarette Other Pipe Smokeless Tobacco Marijuana unknown Not Reported
Secondhand Smoke as Child	Exposure	The text term used to indicate whether the patient was exposed to secondhand smoke as a child.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	yes no unknown Not Reported
Smoke Exposure Duration	Exposure	Text term used to describe the length of time the patient was exposed to an environmental factor.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	Six Weeks or More unknown Not Reported
Tobacco Use per Day	Exposure	Numeric value that represents the number of times the patient uses tobacco each day.	False	Smoking Exposure is "Yes - Smoking Exposure"	String	
Smokeless Tobacco Quit Age	Exposure	Smokeless tobacco quit age	False	Smoking Exposure is "Yes - Smoking Exposure"	String	
Yes - Alcohol Exposure	Exposure	Individual has been exposed to alcohol	False		String	
Alcohol Days Per Week	Exposure	Numeric value used to describe the average number of days each week that a person consumes an alcoholic beverage.	False	Alcohol Exposure is "Yes - Alcohol Exposure"	String	
Alcohol Drinks Per Day	Exposure	Numeric value used to describe the average number of alcoholic beverages a person consumes per day.	False	Alcohol Exposure is "Yes - Alcohol Exposure"	String	
Alcohol History	Exposure	A response to a question that asks whether the participant has consumed at least 12 drinks of any kind of alcoholic beverage in their lifetime.	False	Alcohol Exposure is "Yes - Alcohol Exposure"	String	yes no unknown Not Reported
Alcohol Intensity	Exposure	Category to describe the patient's current level of alcohol use as self-reported by the patient.	False	Alcohol Exposure is "Yes - Alcohol Exposure"	String	Drinker Heavy Drinker Lifelong Non-Drinker Non-Drinker Occasional Drinker unknown Not Reported
Alcohol Type	Exposure	Type of alcohol use	False	Alcohol Exposure is "Yes - Alcohol Exposure"	String	Beer Liquor Other Wine unknown Not Reported
Marijuana smoke	Exposure	Marijuana smoke exposure	False		String	
Marijuana Use Per Week	Exposure	Numeric value that represents the number of times the patient uses marijuana each day.	False	Type is "Marijuana smoke"	String	
Relative with Cancer History	Family History	The yes/no/unknown indicator used to describe whether any of the patient's relatives have a history of cancer.	False		String	Yes - Cancer History Relative None unknown Not Reported
Family Member Vital Status Indicator	Family History,Clinical Data Tier 2	The response indicates whether the family member of the patient with a history of cancer is alive. (Extension to GDC attributes in Family History Tier 1)	False		String	Vital Status Alive Vital Status Dead unknown Not Reported
Known Genetic Predisposition Mutation	Family History,Clinical Data Tier 2	A yes/no/unknown indicator to identify whether there is a known genetic predisposition mutation present in the patient.	False		String	yes no unknown
Hereditary Cancer Predisposition Syndrome	Family History,Clinical Data Tier 2	History of presence of inherited genetic predisposition syndrome that confers heightened susceptibility to cancer in the patient.	False		String	Alpha-1 antitrypsin Attenuated familial adenomatous polyposis BAP1 mutant disease Beckwith-Wiedemann Biliary disorder Birt-Hogg-Dube syndrome Carney complex Cirrhosis unknown etiology Constitutional mismatch repair deficiency Familial adenomatous polyposis Familial gastrointestinal stromal tumor Familial pancreatic cancer Familial prostate cancer Familial renal cancer Fanconi anemia Glycogen Storage Disease Gorlin syndrome Hereditary breast–ovarian cancer syndrome Hereditary diffuse gastric cancer Hereditary leiomyoma-renal cell carcinoma Hereditary melanoma Hereditary mixed polyposis syndrome Hereditary papillary RCC Hereditary papillary renal cell carcinoma Hereditary paraganglioma–pheochromocytoma syndrome Hereditary renal oncocytoma Hereditary retinoblastoma Juvenile polyposis syndrome Li-Fraumeni syndrome Lynch syndrome Melanoma–astrocytoma syndrome Multiple endocrine neoplasia type I Multiple endocrine neoplasia type II MUTYH-associated polyposis Nevoid basal cell carcinoma syndrome Not Applicable Not Reported Peutz–Jeghers syndrome Cowden syndrome Rhabdoid tumor predisposition syndrome type I Rhabdoid tumor predisposition syndrome type II Rubinstein-Taybi syndrome SDH associated renal cancer Serrated polyposis syndrome Tuberous sclerosis complex Turcot syndrome Tyrosinemia unknown von Hippel-Lindau Syndrome
Cancer Associated Gene Mutations	Family History,Clinical Data Tier 2	Type of inherited germline or other gene mutations that confers heightened susceptibility to cancer identified in patient history	False		String	APC mutation ALK mutation ARF mutation ATM mutation ATRX mutation ACVR1 mutation BAP1 mutation BMPR1A mutation BLM mutation BRCA1 mutation BRCA1 and 2 mutation BRCA2 mutation BRAF mutation CDH1 mutation CDKN2A mutation CDKN2A and p14ARF mutation CHK mutation ETV6 mutation EGFR mutation FH mutation FLCN mutation GREM1 mutation HOXB13 mutation H3K27M mutation H3G34R/V mutation IKZF1 mutation KIT mutation KRAS mutation MAX mutation MEN1 mutation MET mutation MLH1 mutation MSH2 mutation MSH6 mutation MUTYH mutation NF1 mutation NF2 mutation Not Applicable Not Reported p14ARF mutation PALB2 mutation PAX5 mutation PDGFRA mutation PHOX2B mutation PMS2 mutation PolD mutation PolE mutation POT1 mutation PRKAR1A mutation PTCH mutation PTEN mutation ROS1 mutation RB1 mutation RET mutation SDHAF2 mutation SDHB mutation SDHC mutation SDHD mutation SETD2 mutation SMAD4 mutation SMARCA4 mutation SMARCB1 mutation STK11 mutation TMEM127 mutation TP53 mutation TSC1 mutation TSC2 mutation unknown VHL mutation
Relationship Gender	Family History	The text term used to describe the gender of the patient's relative with a history of cancer.	False	Relative with Cancer History is "Yes - Cancer History Relative"	String	Female Male unknown Unspecified Not Reported
Relationship Age at Diagnosis	Family History	The age (in years) when the patient's relative was first diagnosed.	False	Relative with Cancer History is "Yes - Cancer History Relative"	String	
Relationship Primary Diagnosis	Family History	The text term used to describe the malignant diagnosis of the patient's relative with a history of cancer.	False	Relative with Cancer History is "Yes - Cancer History Relative"	String	Adrenal Gland Cancer Basal Cell Cancer Bile Duct Cancer Bladder Cancer Blood Cancer Bone Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Chondrosarcoma CNS Cancer Colorectal Cancer Esophageal Cancer Ewing Sarcoma Gallbladder Cancer Gastric Cancer Glioblastoma Gynecologic Cancer Head and Neck Cancer Hematologic Cancer Kaposi Sarcoma Kidney Cancer Laryngeal Cancer Leukemia Liver Cancer Lung Cancer Lymph Node Cancer Lymphoma Melanoma Mesothelioma Multiple Myeloma Neuroblastoma Osteosarcoma Ovarian Cancer Pancreas Cancer Prostate Cancer Rectal Cancer Rhabdomyosarcoma Sarcoma Skin Cancer Spleen Cancer Testicular Cancer Throat Cancer Thyroid Cancer Tongue Cancer Tonsillar Cancer Uterine Cancer Wilms Tumor unknown Not Reported
Relationship Type	Family History	The subgroup that describes the state of connectedness between members of the unit of society organized around kinship ties.	False	Relative with Cancer History is "Yes - Cancer History Relative"	String	Adopted Daughter Adopted Son Adoptive Brother Adoptive Father Adoptive Mother Adoptive Sister Aunt Brother Brother-in-law Child Cousin Daughter Daughter-in-law Domestic Partner Father Father-in-law Female Cousin First Cousin First Cousin Once Removed Foster Brother Foster Daughter Foster Father Foster Mother Foster Sister Foster Son Fraternal Twin Brother Fraternal Twin Sibling Fraternal Twin Sister Full Brother Full Sister Grand Nephew Grand Niece Grandchild Granddaughter Grandfather Grandmother Grandparent Grandson Great Grandchild Half Brother Half Sibling Half Sister Husband Identical Twin Brother Identical Twin Sibling Identical Twin Sister Legal Guardian Male Cousin Maternal Aunt Maternal First Cousin Maternal First Cousin Once Removed Maternal Grandfather Maternal Grandmother Maternal Grandparent Maternal Great Aunt Maternal Great Grandparent Maternal Great Uncle Maternal Half Brother Maternal Half Sibling Maternal Half Sister Maternal Uncle Mother Mother-in-law Natural Brother Natural Child Natural Daughter Natural Father Natural Grandchild Natural Grandfather Natural Grandmother Natural Grandparent Natural Mother Natural Parent Natural Sibling Natural Sister Natural Son Nephew Niece Niece Second Degree Relative Other Parent Paternal Aunt Paternal First Cousin Paternal First Cousin Once Removed Paternal Grandfather Paternal Grandmother Paternal Grandparent Paternal Great Aunt Paternal Great Grandparent Paternal Great Uncle Paternal Half Brother Paternal Half Sibling Paternal Half Sister Paternal Uncle Refused Sibling Sister Sister-in-law Son Son-in-law Spouse Step Child Step Sibling Stepbrother Stepdaughter Stepfather Stepmother Stepsister Stepson Twin Sibling Uncle Unrelated Ward Wife unknown Not Reported
Yes - Cancer History Relative	Family History	Individual has a relative with cancer history	False		String	
Relatives with Cancer History Count	Family History	The number of relatives the patient has with a known history of cancer.	False	Relative with Cancer History is "Yes - Cancer History Relative"	String	
Days to Follow Up	Follow Up	Number of days between the date used for index and the date of the patient's last follow-up appointment or contact. If not applicable please enter 'Not Applicable'	True		String	
Adverse Event	Follow Up	Text that represents the Common Terminology Criteria for Adverse Events low level term name for an adverse event.	False		String	Abdominal Distension Abdominal Infection Abdominal Pain Abdominal Soft Tissue Necrosis Abducens Nerve Disorder Accessory Nerve Disorder Acidosis Acoustic Nerve Disorder NOS Activated Partial Thromboplastin Time Prolonged Acute Coronary Syndrome Acute Kidney Injury Adrenal Insufficiency Adult Respiratory Distress Syndrome Agitation Akathisia Alanine Aminotransferase Increased Alcohol Intolerance Alkaline Phosphatase Increased Alkalosis Allergic Reaction Allergic Rhinitis Alopecia Amnesia Anal Fistula Anal Hemorrhage Anal Mucositis Anal Necrosis Anal Pain Anal Stenosis Anal Ulcer Anaphylaxis Anemia Ankle Fracture Anorectal Infection Anorexia Anorgasmia Anxiety Aortic Injury Aortic Valve Disease Aphonia Apnea Appendicitis Appendicitis Perforated Arachnoiditis Arterial Injury Arteritis Infective Arthralgia Arthritis Ascites Aspartate Aminotransferase Increased Aspiration Asystole Ataxia Atelectasis Atrial Fibrillation Atrial Flutter Atrioventricular Block Complete Atrioventricular Block First Degree Autoimmune Disorder Avascular Necrosis Azoospermia Back Pain Bile Duct Stenosis Biliary Anastomotic Leak Biliary Fistula Biliary Tract Infection Bladder Anastomotic Leak Bladder Infection Bladder Perforation Bladder Spasm Bloating Blood and Lymphatic System Disorders Other Blood Antidiuretic Hormone Abnormal Blood Bilirubin Increased Blood Corticotrophin Decreased Blood Gonadotrophin Abnormal Blood Prolactin Abnormal Blurred Vision Body Odor Bone Infection Bone Marrow Hypocellular Bone Pain Brachial Plexopathy Breast Atrophy Breast Infection Breast Pain Bronchial Fistula Bronchial Infection Bronchial Obstruction Bronchial Stricture Bronchopleural Fistula Bronchopulmonary Hemorrhage Bronchospasm Bruising Bullous Dermatitis Burn Buttock Pain Capillary Leak Syndrome Carbon Monoxide Diffusing Capacity Decreased Cardiac Arrest Cardiac Disorders Other Cardiac Troponin I Increased Cardiac Troponin T Increased Cataract Catheter Related Infection CD4 Lymphocytes Decreased Cecal Hemorrhage Cecal Infection Central Nervous System Necrosis Cerebrospinal Fluid Leakage Cervicitis Infection Cheilitis Chest Pain Cardiac Chest Wall Pain Chills Cholecystitis Cholesterol High Chronic Kidney Disease Chylothorax Cognitive Disturbance Colitis Colonic Fistula Colonic Hemorrhage Colonic Obstruction Colonic Perforation Colonic Stenosis Colonic Ulcer Concentration Impairment Conduction Disorder Confusion Congenital Familial and Genetic Disorders Other Conjunctivitis Conjunctivitis Infective Constipation Constrictive Pericarditis Corneal Infection Corneal Ulcer Cough CPK Increased Cranial Nerve Infection Creatinine Increased Cushingoid Cystitis Noninfective Cytokine Release Syndrome Death Neonatal Death NOS Dehydration Delayed Orgasm Delayed Puberty Delirium Delusions Dental Caries Depressed Level of Consciousness Depression Dermatitis Radiation Device Related Infection Diarrhea Disseminated Intravascular Coagulation Dizziness Dry Eye Dry Mouth Dry Skin Duodenal Fistula Duodenal Hemorrhage Duodenal Infection Duodenal Obstruction Duodenal Perforation Duodenal Stenosis Duodenal Ulcer Dysarthria Dysesthesia Dysgeusia Dysmenorrhea Dyspareunia Dyspepsia dysphagia Dysphasia dyspnea Ear and Labyrinth Disorders Other Ear Pain Edema Cerebral Edema Face Edema Limbs Edema Trunk Ejaculation Disorder Ejection Fraction Decreased Electrocardiogram QT Corrected Interval Prolonged Encephalitis Infection Encephalomyelitis Infection Encephalopathy Endocarditis Infective Endocrine Disorders Other Endophthalmitis Enterocolitis Enterocolitis Infectious Enterovesical Fistula Epistaxis Erectile Dysfunction Erythema Multiforme Erythroderma Esophageal Anastomotic Leak Esophageal Fistula Esophageal Hemorrhage Esophageal Infection Esophageal Necrosis Esophageal Obstruction Esophageal Pain Esophageal Perforation Esophageal Stenosis Esophageal Ulcer Esophageal Varices Hemorrhage Esophagitis Euphoria Exostosis External Ear Inflammation External Ear Pain Extraocular Muscle Paresis Extrapyramidal Disorder Eye Disorders Other Eye Infection Eye Pain Eyelid Function Disorder Facial Muscle Weakness Facial Nerve Disorder Facial Pain Fall Fallopian Tube Anastomotic Leak Fallopian Tube Obstruction Fallopian Tube Perforation Fallopian Tube Stenosis Fat Atrophy Fatigue Febrile Neutropenia Fecal Incontinence Female Genital Tract Fistula Feminization Acquired Fetal Death Fetal Growth Retardation Fever Fibrinogen Decreased Fibrosis Deep Connective Tissue Flank Pain Flashing Lights Flatulence Floaters Flu Like Symptoms Flushing Forced Expiratory Volume Decreased Fracture Gait Disturbance Gallbladder Fistula Gallbladder Infection Gallbladder Necrosis Gallbladder Obstruction Gallbladder Pain Gallbladder Perforation Gastric Anastomotic Leak Gastric Fistula Gastric Hemorrhage Gastric Necrosis Gastric Perforation Gastric Stenosis Gastric Ulcer Gastritis Gastroesophageal Reflux Disease Gastrointestinal Anastomotic Leak Gastrointestinal Disorders Other Gastrointestinal Fistula Gastrointestinal Pain Gastrointestinal Stoma Necrosis Gastroparesis General Disorders and Administration Site Conditions Other Generalized Muscle Weakness Genital Edema GGT Increased Gingival Pain Glaucoma Glossopharyngeal Nerve Disorder Glucose Intolerance Growth Accelerated Growth Hormone Abnormal Growth Suppression Gum Infection Gynecomastia Hallucinations Haptoglobin Decreased Head Soft Tissue Necrosis Headache Hearing Impaired Heart Failure Hematoma Hematosalpinx Hematuria Hemoglobin Increased Hemoglobinuria Hemolysis Hemolytic Uremic Syndrome Hemorrhoidal Hemorrhage Hemorrhoids Hepatic Failure Hepatic Hemorrhage Hepatic Infection Hepatic Necrosis Hepatic Pain Hepatitis Viral Hepatobiliary Disorders Other Hiccups Hip Fracture Hirsutism Hoarseness Hot Flashes Hydrocephalus Hypercalcemia Hyperglycemia Hyperhidrosis Hyperkalemia Hypermagnesemia Hypernatremia Hyperparathyroidism Hypersomnia Hypertension Hyperthyroidism Hypertrichosis Hypertriglyceridemia Hyperuricemia Hypoalbuminemia Hypocalcemia Hypoglossal Nerve Disorder Hypoglycemia Hypohidrosis Hypokalemia Hypomagnesemia Hyponatremia Hypoparathyroidism Hypophosphatemia Hypotension Hypothermia Hypothyroidism Hypoxia Ileal Fistula Ileal Hemorrhage Ileal Obstruction Ileal Perforation Ileal Stenosis Ileal Ulcer Ileus Immune System Disorders Other Infections and Infestations Other Infective Myositis Infusion Related Reaction Infusion Site Extravasation Injection Site Reaction Injury to Carotid Artery Injury to Inferior Vena Cava Injury to Jugular Vein Injury to Superior Vena Cava Injury Poisoning and Procedural Complications Other INR Increased Insomnia Intestinal Stoma Leak Intestinal Stoma Obstruction Intestinal Stoma Site Bleeding Intra-Abdominal Hemorrhage Intracranial Hemorrhage Intraoperative Arterial Injury Intraoperative Breast Injury Intraoperative Cardiac Injury Intraoperative Ear Injury Intraoperative Endocrine Injury Intraoperative Gastrointestinal Injury Intraoperative Head and Neck Injury Intraoperative Hemorrhage Intraoperative Hepatobiliary Injury Intraoperative Musculoskeletal Injury Intraoperative Neurological Injury Intraoperative Ocular Injury Intraoperative Renal Injury Intraoperative Reproductive Tract Injury Intraoperative Respiratory Injury Intraoperative Skin Injury Intraoperative Splenic Injury Intraoperative Urinary Injury Intraoperative Venous Injury Investigations Other Iron Overload Irregular Menstruation Irritability Ischemia Cerebrovascular IVth Nerve Disorder Jejunal Fistula Jejunal Hemorrhage Jejunal Obstruction Jejunal Perforation Jejunal Stenosis Jejunal Ulcer Joint Effusion Joint Infection Joint Range of Motion Decreased Joint Range of Motion Decreased Cervical Spine Joint Range of Motion Decreased Lumbar Spine Keratitis Kidney Anastomotic Leak Kidney Infection Kyphosis Lactation Disorder Large Intestinal Anastomotic Leak Laryngeal Edema Laryngeal Fistula Laryngeal Hemorrhage Laryngeal Inflammation Laryngeal Mucositis Laryngeal Obstruction Laryngeal Stenosis Laryngitis Laryngopharyngeal Dysesthesia Laryngospasm Left Ventricular Systolic Dysfunction Lethargy Leukemia Secondary to Oncology Chemotherapy Leukocytosis Leukoencephalopathy Libido Decreased Libido Increased Lip Infection Lip Pain Lipase Increased Lipohypertrophy Localized Edema Lordosis Lower Gastrointestinal Hemorrhage Lung Infection Lymph Gland Infection Lymph Leakage Lymph Node Pain Lymphedema Lymphocele Lymphocyte Count Decreased Lymphocyte Count Increased Malabsorption Malaise Mania Mediastinal Hemorrhage Mediastinal Infection Memory Impairment Meningismus Meningitis Menopause Menorrhagia Metabolism and Nutrition Disorders Other Middle Ear Inflammation Mitral Valve Disease Mobitz (Type) II Atrioventricular Block Mobitz Type I Movements Involuntary Mucosal Infection Mucositis Oral Multi-Organ Failure Muscle Weakness Left-Sided Muscle Weakness Lower Limb Muscle Weakness Right-Sided Muscle Weakness Trunk Muscle Weakness Upper Limb Musculoskeletal and Connective Tissue Disorders Other Musculoskeletal Deformity Myalgia Myelitis Myelodysplastic Syndrome Myocardial Infarction Myocarditis Myositis Nail Discoloration Nail Infection Nail Loss Nail Ridging Nasal Congestion Nausea Neck Edema Neck Pain Neck Soft Tissue Necrosis Neoplasms Benign Malignant and Unspecified (Incl Cysts and Polyps) Other Nervous System Disorders Other Neuralgia Neutrophil Count Decreased Night Blindness Nipple Deformity Non-Cardiac Chest Pain Nystagmus Obesity Obstruction Gastric Oculomotor Nerve Disorder Olfactory Nerve Disorder Oligospermia Optic Nerve Disorder Oral Cavity Fistula Oral Dysesthesia Oral Hemorrhage Oral Pain Osteonecrosis of Jaw Osteoporosis Otitis Externa Otitis Media Ovarian Hemorrhage Ovarian Infection Ovarian Rupture Ovulation Pain Pain Pain in Extremity Pain of Skin Palmar-Plantar Erythrodysesthesia Syndrome Palpitations Pancreas Infection Pancreatic Anastomotic Leak Pancreatic Duct Stenosis Pancreatic Enzymes Decreased Pancreatic Fistula Pancreatic Hemorrhage Pancreatic Necrosis Pancreatitis Papilledema Papulopustular Rash Paresthesia Paronychia Paroxysmal Atrial Tachycardia Pelvic Floor Muscle Weakness Pelvic Infection Pelvic Pain Pelvic Soft Tissue Necrosis Penile Infection Penile Pain Perforation Bile Duct Pericardial Effusion Pericardial Tamponade Pericarditis Perineal Pain Periodontal Disease Periorbital Edema Periorbital Infection Peripheral Ischemia Peripheral Motor Neuropathy Peripheral Nerve Infection Peripheral Sensory Neuropathy Peritoneal Infection Peritoneal Necrosis Personality Change Phantom Pain Pharyngeal Anastomotic Leak Pharyngeal Fistula Pharyngeal Hemorrhage Pharyngeal Mucositis Pharyngeal Necrosis Pharyngeal Stenosis Pharyngitis Pharyngolaryngeal Pain Phlebitis Phlebitis Infective Photophobia Photosensitivity Platelet Count Decreased Pleural Effusion Pleural Hemorrhage Pleural Infection Pleuritic Pain Pneumonitis Pneumothorax Portal Hypertension Portal Vein Thrombosis Postnasal Drip Postoperative Hemorrhage Postoperative Thoracic Procedure Complication Precocious Puberty Pregnancy Puerperium and Perinatal Conditions Other Premature Delivery Premature Menopause Presyncope Proctitis Productive Cough Prolapse of Intestinal Stoma Prolapse of Urostomy Prostate Infection Prostatic Hemorrhage Prostatic Obstruction Prostatic Pain Proteinuria Pruritus Psychiatric Disorders Other Psychosis Pulmonary Edema Pulmonary Fibrosis Pulmonary Fistula Pulmonary Hypertension Pulmonary Valve Disease Purpura Pyramidal Tract Syndrome Radiation Recall Reaction (Dermatologic) Radiculitis Rash Acneiform Rash Maculo-Papular Rash Pustular Rectal Anastomotic Leak Rectal Fistula Rectal Hemorrhage Rectal Mucositis Rectal Necrosis Rectal Obstruction Rectal Pain Rectal Perforation Rectal Stenosis Rectal Ulcer Recurrent Laryngeal Nerve Palsy Renal and Urinary Disorders Other Renal Calculi Renal Colic Renal Hemorrhage Reproductive System and Breast Disorders Other Respiratory Failure Respiratory Thoracic and Mediastinal Disorders Other Restlessness Restrictive Cardiomyopathy Retinal Detachment Retinal Tear Retinal Vascular Disorder Retinoic Acid Syndrome Retinopathy Retroperitoneal Hemorrhage Reversible Posterior Leukoencephalopathy Syndrome Rhinitis Infective Right Ventricular Dysfunction Salivary Duct Inflammation Salivary Gland Fistula Salivary Gland Infection Scalp Pain Scleral Disorder Scoliosis Scrotal Infection Scrotal Pain Seizure Sepsis Seroma Serum Amylase Increased Serum Sickness Sick Sinus Syndrome Sinus Bradycardia Sinus Disorder Sinus Pain Sinus Tachycardia Sinusitis Skin and Subcutaneous Tissue Disorders Other Skin Atrophy Skin Hyperpigmentation Skin Hypopigmentation Skin Induration Skin Infection Skin Ulceration Sleep Apnea Small Intestinal Anastomotic Leak Small Intestinal Mucositis Small Intestinal Obstruction Small Intestinal Perforation Small Intestinal Stenosis Small Intestine Infection Small Intestine Ulcer Sneezing Social Circumstances Other Soft Tissue Infection Soft Tissue Necrosis Lower Limb Soft Tissue Necrosis Upper Limb Somnolence Sore Throat Spasticity Spermatic Cord Anastomotic Leak Spermatic Cord Hemorrhage Spermatic Cord Obstruction Spinal Fracture Spleen Disorder Splenic Infection Stenosis of Gastrointestinal Stoma Stevens-Johnson Syndrome Stoma Site Infection Stomach Pain Stomal Ulcer Stridor Stroke Sudden Death NOS Suicidal Ideation Suicide Attempt Superficial Soft Tissue Fibrosis Superficial Thrombophlebitis Superior Vena Cava Syndrome Supraventricular Tachycardia Surgical and Medical Procedures Other Syncope Telangiectasia Testicular Disorder Testicular Hemorrhage Testicular Pain Thromboembolic Event Thrombotic Thrombocytopenic Purpura Tinnitus Tooth Development Disorder Tooth Discoloration Tooth Infection Toothache Toxic Epidermal Necrolysis Tracheal Fistula Tracheal Hemorrhage Tracheal Mucositis Tracheal Obstruction Tracheal Stenosis Tracheitis Tracheostomy Site Bleeding Transient Ischemic Attacks Treatment Related Secondary Malignancy Tremor Tricuspid Valve Disease Trigeminal Nerve Disorder Trismus Tumor Lysis Syndrome Tumor Pain Typhlitis Unequal Limb Length Unintended Pregnancy Upper Gastrointestinal Hemorrhage Upper Respiratory Infection Ureteric Anastomotic Leak Urethral Anastomotic Leak Urethral Infection Urinary Fistula Urinary Frequency Urinary Incontinence Urinary Retention Urinary Tract Infection Urinary Tract Obstruction Urinary Tract Pain Urinary Urgency Urine Discoloration Urine Output Decreased Urostomy Leak Urostomy Obstruction Urostomy Site Bleeding Urostomy Stenosis Urticaria Uterine Anastomotic Leak Uterine Fistula Uterine Hemorrhage Uterine Infection Uterine Obstruction Uterine Pain Uterine Perforation Uveitis Vaginal Anastomotic Leak Vaginal Discharge Vaginal Dryness Vaginal Fistula Vaginal Hemorrhage Vaginal Infection Vaginal Inflammation Vaginal Obstruction Vaginal Pain Vaginal Perforation Vaginal Stricture Vaginismus Vagus Nerve Disorder Vas Deferens Anastomotic Leak Vascular Access Complication Vascular Disorders Other Vasculitis Vasovagal Reaction Venous Injury Ventricular Arrhythmia Ventricular Fibrillation Ventricular Tachycardia Vertigo Vestibular Disorder Virilization Visceral Arterial Ischemia Vital Capacity Abnormal Vitreous Hemorrhage Voice Alteration Vomiting Vulval Infection Watering Eyes Weight Gain Weight Loss wheezing White Blood Cell Decreased Wolff-Parkinson-White Syndrome Wound Complication Wound Dehiscence Wound Infection Wrist Fracture
Barretts Esophagus Goblet Cells Present	Follow Up	Presence or absennce of Barretts esophagus goblet cells.	False		String	yes no
BMI	Follow Up	A calculated numerical quantity that represents an individual's weight to height ratio.	False		String	
Cause of Response	Follow Up	The text term used to describe the suspected cause or reason for the patient disease response.	False		String	
Comorbidity	Follow Up	The text term used to describe a comorbidity disease, which coexists with the patient's malignant disease.	False		String	Acute Renal Failure Adenocarcinoma Adrenocortical Insufficiency Adenomatous Polyposis Coli Allergies Alpha-1 Antitrypsin Anemia Anxiety Arrhythmia Arthritis Asthma Atrial Fibrillation Avascular Necrosis Barrett's Esophagus Basal Cell Carcinoma Beckwith-Wiedemann Behcet's Disease Biliary Disorder Blood Clots Bone Fracture(s) Bronchitis Calcium Channel Blockers Cancer Cataracts Celiac Disease Cirrhosis unknown Etiology Cerebrovascular Disease Cholelithiasis Chronic Renal Failure Colon Polyps Common Variable Immunodeficiency Congestive Heart Failure (CHF) Connective Tissue Disorder COPD Coronary Artery Disease Crohn's Disease Cryptogenic Organizing Pneumonia Deep Vein Thrombosis / Thromboembolism Denys-Drash Syndrome Depression Diabetes Type II Diabetic Neuropathy Diet Controlled Diabetes Diverticulitis DVT/PE Dyslipidemia Epilepsy Eczema Epstein-Barr Virus Familial Adenomatous Polyposis Fanconi Anemia Fibrosis Gastroesophageal Reflux Disease GERD Glaucoma Glycogen Storage Disease Gout Gonadal Dysfunction Gorlin Syndrome H. pylori Infection Hashimoto's Thyroiditis Headache Heart Disease Hemihypertrophy Hemorrhagic Cystitis Hepatitis Hepatitis A Infection Hepatitis B Infection Hepatitis C Infection Chronic Hepatitis Hereditary Non-polyposis Colon Cancer Herpes High Grade Liver Dysplastic Nodule HIV / AIDS Human Papillomavirus Infection HUS/TTP Hypercholesterolemia Hypercalcemia Hyperglycemia Hyperlipidemia Hypertension Hypospadias Hypothyroidism Inflammatory Bowel Disease Insulin Controlled Diabetes Interstitial Pneumontis or ARDS Intraductal Papillary Mucinous Neoplasm Iron Overload Ischemic Heart Disease ITP Joint Replacement Kidney Disease Liver Cirrhosis (Liver Disease) Liver Toxicity (Non-Infectious) Li-Fraumeni Syndrome Low Grade Liver Dysplastic Nodule Lupus Lynch Syndrome MAI Myasthenia Gravis Myocardial Infarction Neuroendocrine Tumor Nonalcoholic Steatohepatitis Obesity Organ transplant (site) Osteoarthritis Osteoporosis or Osteopenia Other Other Cancer Within 5 Years Other Nonmalignant Systemic Disease Other Pulmonary Complications Pancreatitis Pain (Various) Peptic Ulcer (Ulcer) Peripheral Neuropathy Peripheral Vascular Disease Peutz-Jeghers Disease Pregnancy in Patient or Partner Primary Sclerosing Cholangitis Psoriasis Pulmonary Fibrosis Pulmonary Hemorrhage Renal Failure (Requiring Dialysis) Renal Dialysis Renal Insufficiency Rheumatologic Disease Rheumatoid Arthritis Rubinstein-Taybi Syndrome Sarcoidosis Seizure Sleep apnea Smoking Steatosis Stroke Transient Ischemic Attack Tuberculosis Turcot Syndrome Tyrosinemia Ulcerative Colitis Wagr Syndrome unknown Not Reported
Comorbidity Method of Diagnosis	Follow Up	The text term used to describe the method used to diagnose the patient's comorbidity disease.	False		String	Histology Pathology Radiology unknown Not Reported
Days to Adverse Event	Follow Up	Number of days between the date used for index and the date of the patient's adverse event. If not applicable please enter 'Not Applicable'	False		String	
Days to Comorbidity	Follow Up	Number of days between the date used for index and the date the patient was diagnosed with a comorbidity. If not applicable please enter 'Not Applicable'	False		String	
Diabetes Treatment Type	Follow Up	Text term used to describe the types of treatment used to manage diabetes.	False		String	Alpha-Glucosidase Inhibitor Biguanide Diet Injected Insulin Insulin Oral Hypoglycemic Sulfonylurea Thiazolidinedione Other unknown Not Reported
Disease Response	Follow Up	Code assigned to describe the patient's response or outcome to the disease.	False		String	AJ-Adjuvant Therapy BED-Biochemical Evidence of Disease CPD-Clinical Progression CR-Complete Response CRU-Complete Response Unconfirmed DU-Disease Unchanged IMR-Immunoresponse IPD-Immunoprogression MR-Minimal/Marginal response MX-Mixed Response Non-CR/Non-PD-Non-CR/Non-PD NPB-No Palliative Benefit NR-No Response PA-Palliative Therapy PB-Palliative Benefit PD-Progressive Disease PDM-Persistent Distant Metastasis PLD-Persistent Locoregional Disease PPD-Pseudoprogression PR-Partial Response PSR-Pseudoresponse RD-Responsive Disease RP-Response RPD-Radiographic Progressive Disease sCR-Stringent Complete Response SD-Stable Disease SPD-Surgical Progression TE-Too Early TF-Tumor Free VGPR-Very Good Partial Response WT-With Tumor unknown Not Reported
DLCO Ref Predictive Percent	Follow Up	The value, as a percentage of predicted lung volume, measuring the amount of carbon monoxide detected in a patient's lungs.	False		String	
ECOG Performance Status	Follow Up	The ECOG functional performance status of the patient/participant.	False		String	"0" "1" "2" "3" "4" "5" "0.0" "1.0" "2.0" "3.0" "4.0" "5.0" unknown Not Reported
FEV1 FVC Post Bronch Percent	Follow Up	Percentage value to represent result of Forced Expiratory Volume in 1 second (FEV1) divided by the Forced Vital Capacity (FVC) post-bronchodilator.	False		String	
FEV 1 FVC Pre Bronch Percent	Follow Up	Percentage value to represent result of Forced Expiratory Volume in 1 second (FEV1) divided by the Forced Vital Capacity (FVC) pre-bronchodilator.	False		String	
FEV1 Ref Post Bronch Percent	Follow Up	The percentage comparison to a normal value reference range of the volume of air that a patient can forcibly exhale from the lungs in one second post-bronchodilator.	False		String	
FEV1 Ref Pre Bronch Percent	Follow Up	The percentage comparison to a normal value reference range of the volume of air that a patient can forcibly exhale from the lungs in one second pre-bronchodilator.	False		String	
Height	Follow Up	The height of the patient in centimeters.	False		String	
Hepatitis Sustained Virological Response	Follow Up	The yes/no/unknown indicator used to describe whether the patient received treatment for a risk factor the patient had at the time of or prior to their diagnosis.	False		String	yes no unknown Not Reported
HPV Positive Type	Follow Up	Text classification to represent the strain or type of human papillomavirus identified in an individual.	False		String	"16" "18" "26" "31" "33" "35" "39" "45" "51" "52" "53" "56" "58" "59" "63" "66" "68" "70" "73" "82" Other unknown Not Reported
Karnofsky Performance Status	Follow Up	Text term used to describe the classification used of the functional capabilities of a person.	False		String	"0" "10" "20" "30" "40" "50" "60" "70" "80" "90" "100" unknown Not Reported
Menopause Status	Follow Up	Text term used to describe the patient's menopause status.	False		String	Premenopausal Perimenopausal Postmenopausal unknown Not Reported
Pancreatitis Onset Year	Follow Up	Date of onset of pancreatitis.	False		String	
Reflux Treatment Type	Follow Up	Text term used to describe the types of treatment used to manage gastroesophageal reflux disease (GERD).	False		String	Antacids H2 Blockers Medically Treated No Treatment Not Applicable Not Reported Proton Pump Inhibitors Surgically Treated unknown
Risk Factor	Follow Up	The text term used to describe a risk factor the patient had at the time of or prior to their diagnosis.	False		String	Alcohol Consumption Alcoholic Liver Disease Allergy Animal NOS Allergy Ant Allergy Bee Allergy Cat Allergy Dairy or Lactose Allergy Dog Allergy Eggs Allergy Food NOS Allergy Fruit Allergy Meat Allergy Mold or Dust Allergy Nuts Allergy Processed Foods Allergy Seafood Allergy Wasp Alpha-1 Antitrypsin Deficiency Autoimmune Atrophic Chronic Gastritis Barrett's Esophagus Beckwith-Wiedemann Behcet's Disease Cancer Cholelithiasis Chronic Hepatitis Cirrhosis Colon Polyps Common variable immune deficiency (CVID) Denys-Drash Syndrome Diabetes NOS Diabetes Type I Diabetes Type II Diet Diverticulitis Endometriosis Endosalpingiosis Eczema Epstein-Barr Virus Familial Adenomatous Polyposis Fanconi Anemia Fibrosis Gastric Polyp(s) Gilbert's Syndrome Gorlin Syndrome Hashimoto's Thyroiditis Hay Fever Headache Helicobacter Pylori-Associated Gastritis Hematologic Disorder NOS Hemihypertrophy Hemochromatosis Hepatic Encephalopathy Hepatitis B Infection Hepatitis C Infection Hepatitis NOS High Grade Dysplasia HIV Human Papillomavirus Infection Hypospadias Intestinal Metaplasia Iron Overload Li-Fraumeni Syndrome Low Grade Dysplasia Lymphocytic Thyroiditis Lynch Syndrome Myasthenia Gravis Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Obesity Oral Contraceptives Pancreatitis Parasitic Disease of Biliary Tract Primary Sclerosing Cholangitis Recurrent Pyogenic Cholangitis Reflux Disease Rheumatoid Arthritis Rubinstein-Taybi Syndrome Sarcoidosis Seizure Sensory Changes Serous tubal intraepithelial carcinoma (STIC) Steatosis Tattoo Thyroid Nodular Hyperplasia Tobacco NOS Tobacco Smokeless Tobacco Smoking Turcot Syndrome Undescended Testis Vision Changes Wagr Syndrome unknown Not Reported
Risk Factor Treatment	Follow Up	The yes/no/unknown indicator used to describe whether the patient received treatment for a risk factor the patient had at the time of or prior to their diagnosis.	False		String	yes no unknown Not Reported
Viral Hepatitis Serologies	Follow Up	Text term that describes the kind of serological laboratory test used to determine the patient's hepatitus status.	False		String	HBV Core Antibody HBV DNA HBV Genotype HBV Surface Antibody HCV Genotype Hepatitis B Surface Antigen Hepatitis C Antibody Hepatitis C Virus RNA unknown Not Reported
Weight	Follow Up	The weight of the patient measured in kilograms.	False		String	
Adverse Event Grade	Follow Up	The text term used to describe a specific histone variants, which are proteins that substitute for the core canonical histones.	False		String	Grade 1 Grade 2 Grade 3 Grade 4 Grade 5
AIDS Risk Factors	Follow Up	The text term used to describe a risk factor of the acquired immunodeficiency syndrome (AIDS) that the patient either had at time time of the study or experienced in the past.	False		String	Candidiasis Coccidioidomycosis Cryptococcosis Cytomegalovirus Encephalopathy Herpes Simplex Virus Histoplasmosis Isosporiasis Mycobacterium avium Complex Mycobacterium tuberculosis Mycobacterium NOS Nocardiosis Pneumocystis Pneumonia pneumonia Progressive Multifocal Leukoencephalopathy Salmonella Septicemia Toxoplasmosis Wasting Syndrome
Body Surface Area	Follow Up	Numeric value used to represent the 2-dimensional extent of the body surface relating height to weight.	False		String	
CD4 Count	Follow Up	The text term used to describe the outcome of the procedure to determine the amount of the CD4 expressing cells in a sample.	False		String	
CDC HIV Risk Factors	Follow Up	The text term used to describe a risk factor for human immunodeficiency virus, as described by the Center for Disease Control.	False		String	Hemophiliac Heterosexual Contact Homosexual Contact Intravenous Drug User None Transfusion Recipient unknown Not Reported
Days to Imaging	Follow Up	Number of days between the date used for index and the date the imaging or scan was performed on the patient. If not applicable please enter 'Not Applicable'	False		String	
Evidence of Recurrence Type	Follow Up	The text term used to describe the type of evidence used to determine whether the patient's disease recurred	False		String	Biopsy with Histologic Confirmation Convincing Image Source Positive Biomarkers
HAART Treatment Indicator	Follow Up	The text term used to indicate whether the patient received Highly Active Antiretroviral Therapy (HAART).	False		String	yes no unknown Not Reported
HIV Viral Load	Follow Up	Numeric value that represents the concentration of an analyte or aliquot extracted from the sample or sample portion, measured in milligrams per milliliter.	False		String	
Hormonal Contraceptive Use	Follow Up	The text term used to indicate whether the patient used hormonal contraceptives.	False		String	Current User Former User Never Used unknown Not Reported
Hysterectomy Margins Involved	Follow Up	The text term used to indicate whether the patient's disease was determined to be involved based on the surgical margins of the hysterectomy.	False		String	Bladder Macroscopic Parametrium Microscopic Parametrium None Vagina unknown Not Reported
Hysterectomy Type	Follow Up	The text term used to describe the type of hysterectomy the patient had.	False		String	Hysterectomy NOS Not performed Radical Hysterectomy Simple Hysterectomy unknown Not Reported
Imaging Result	Follow Up	The text term used to describe the result of the imaging or scan performed on the patient.	False		String	positive Indeterminate negative Not Performed unknown Not Reported
Imaging Type	Follow Up	The text term used to describe the type of imaging or scan performed on the patient.	False		String	99mTc Bone Scintigraphy CT Scan MRI PET
Immunosuppressive Treatment Type	Follow Up	The text term used to describe the type of immunosuppresive treatment the patient received.	False		String	Anti-TNFTherapy Azathioprine Cyclophosphamide Methotrexate None Other unknown Not Reported
Nadir CD4 Count	Follow Up	Numeric value that represents the lowest point to which the CD4 count has dropped (nadir).	False		String	
Pregnancy Outcome	Follow Up	The text term used to describe the type of pregnancy the patient had	False		String	Ectopic Pregnancy Induced Abortion Live Birth Miscarriage Stillbirth unknown Not Reported
Recist Targeted Regions Number	Follow Up	Numeric value that represents the number of baseline target lesions, as described by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria	False		String	
Recist Targeted Regions Sum	Follow Up	Numeric value that represents the sum of baseline target lesions, as described by the Response Evaluation Criteria in Solid Tumours (RECIST) criteria.	False		String	
Scan Tracer Used	Follow Up	The text term used to describe the type of tracer used during the imaging or scan of the patient.	False		String	Acetate Axumin Choline PSMA Sodium Fluoride
Days to Recurrence	Follow Up,Diagnosis	Number of days between the date used for index and the date the patient's disease recurred. If not applicable please enter 'Not Applicable'	True	Progression or Recurrence is "Yes - Progression or Recurrence"	String	
Treatment Anatomic Site	Follow Up,Therapy	The text term used to describe the anatomic site of resection; biopsy; tissue or organ of biospecimen origin; progression or recurrent disease; treatment	False		String	Abdomen NOS Abdominal esophagus Accessory sinus NOS Acoustic nerve Adrenal gland NOS Ampulla of Vater Anal canal Anterior 2/3 of tongue NOS Anterior floor of mouth Anterior mediastinum Anterior surface of epiglottis Anterior wall of bladder Anterior wall of nasopharynx Anus NOS Aortic body and other paraganglia Appendix Ascending colon Autonomic nervous system NOS Axillary tail of breast Base of tongue NOS Bladder neck Bladder NOS Blood Body of pancreas Body of penis Body of stomach Bone marrow Bone of limb NOS Bone NOS Bones of skull and face and associated joints Border of tongue Brain stem Brain NOS Branchial cleft Breast NOS Broad ligament Cardia NOS Carotid body Cauda equina Cecum Central portion of breast Cerebellum NOS Cerebral meninges Cerebrum Cervical esophagus Cervix uteri Choroid Ciliary body Cloacogenic zone Colon NOS Commissure of lip Conjunctiva Connective subcutaneous and other soft tissues of abdomen Connective subcutaneous and other soft tissues of head face and neck Connective subcutaneous and other soft tissues of lower limb and hip Connective subcutaneous and other soft tissues of pelvis Connective subcutaneous and other soft tissues of thorax Connective subcutaneous and other soft tissues of trunk NOS Connective subcutaneous and other soft tissues of upper limb and shoulder Connective subcutaneous and other soft tissues NOS Cornea NOS Corpus uteri Cortex of adrenal gland Cranial nerve NOS Craniopharyngeal duct Descended testis Descending colon Dome of bladder Dorsal surface of tongue NOS Duodenum Endocervix Endocrine gland NOS Endometrium Epididymis Esophagus NOS Ethmoid sinus Exocervix External ear External lip NOS External lower lip External upper lip Extrahepatic bile duct Eye NOS Eyelid Fallopian tube Female genital tract NOS Floor of mouth NOS Frontal lobe Frontal sinus Fundus of stomach Fundus uteri Gallbladder Gastric antrum Gastrointestinal tract NOS Glans penis Glottis Greater curvature of stomach NOS Gum NOS Hard palate Head of pancreas Head face or neck NOS Heart Hematopoietic system NOS Hepatic flexure of colon Hypopharyngeal aspect of aryepiglottic fold Hypopharynx NOS Ileum Ill-defined sites within respiratory system Intestinal tract NOS Intra-abdominal lymph nodes Intrahepatic bile duct Intrathoracic lymph nodes Islets of Langerhans Isthmus uteri Jejunum Kidney NOS Labium majus Labium minus Lacrimal gland Laryngeal cartilage Larynx NOS Lateral floor of mouth Lateral wall of bladder Lateral wall of nasopharynx Lateral wall of oropharynx Lesser curvature of stomach NOS Lingual tonsil Lip NOS Liver Long bones of lower limb and associated joints Long bones of upper limb scapula and associated joints Lower gum Lower limb NOS Lower lobe lung Lower third of esophagus Lower-inner quadrant of breast Lower-outer quadrant of breast Lung NOS Lymph node NOS Lymph nodes of axilla or arm Lymph nodes of head face and neck Lymph nodes of inguinal region or leg Lymph nodes of multiple regions Main bronchus Major salivary gland NOS Male genital organs NOS Mandible Maxillary sinus Meckel diverticulum Mediastinum NOS Medulla of adrenal gland Meninges NOS Middle ear Middle lobe lung Middle third of esophagus Mouth NOS Mucosa of lip NOS Mucosa of lower lip Mucosa of upper lip Myometrium Nasal cavity Nasopharynx NOS Nervous system NOS Nipple Occipital lobe Olfactory nerve Optic nerve Orbit NOS Oropharynx NOS Other ill-defined sites Other specified parts of female genital organs Other specified parts of male genital organs Other specified parts of pancreas Ovary Overlapping lesion of accessory sinuses Overlapping lesion of bladder Overlapping lesion of bones joints and articular cartilage Overlapping lesion of bones joints and articular cartilage of limbs Overlapping lesion of brain Overlapping lesion of brain and central nervous system Overlapping lesion of breast Overlapping lesion of cervix uteri Overlapping lesion of colon Overlapping lesion of connective subcutaneous and other soft tissues Overlapping lesion of corpus uteri Overlapping lesion of digestive system Overlapping lesion of endocrine glands and related structures Overlapping lesion of esophagus Overlapping lesion of eye and adnexa Overlapping lesion of female genital organs Overlapping lesion of floor of mouth Overlapping lesion of heart mediastinum and pleura Overlapping lesion of hypopharynx Overlapping lesion of ill-defined sites Overlapping lesion of larynx Overlapping lesion of lip Overlapping lesion of lip oral cavity and pharynx Overlapping lesion of lung Overlapping lesion of major salivary glands Overlapping lesion of male genital organs Overlapping lesion of nasopharynx Overlapping lesion of other and unspecified parts of mouth Overlapping lesion of palate Overlapping lesion of pancreas Overlapping lesion of penis Overlapping lesion of peripheral nerves and autonomic nervous system Overlapping lesion of rectum anus and anal canal Overlapping lesion of respiratory system and intrathoracic organs Overlapping lesion of retroperitoneum and peritoneum Overlapping lesion of skin Overlapping lesion of small intestine Overlapping lesion of stomach Overlapping lesion of tongue Overlapping lesion of tonsil Overlapping lesion of urinary organs Overlapping lesion of vulva Overlapping lesions of oropharynx Palate NOS Pancreas NOS Pancreatic duct Parametrium Parathyroid gland Paraurethral gland Parietal lobe Parotid gland Pelvic bones sacrum coccyx and associated joints Pelvic lymph nodes Pelvis NOS Penis NOS Peripheral nerves and autonomic nervous system of abdomen Peripheral nerves and autonomic nervous system of head face and neck Peripheral nerves and autonomic nervous system of lower limb and hip Peripheral nerves and autonomic nervous system of pelvis Peripheral nerves and autonomic nervous system of thorax Peripheral nerves and autonomic nervous system of trunk NOS Peripheral nerves and autonomic nervous system of upper limb and shoulder Peritoneum NOS Pharynx NOS Pineal gland Pituitary gland Placenta Pleura NOS Postcricoid region Posterior mediastinum Posterior wall of bladder Posterior wall of hypopharynx Posterior wall of nasopharynx Posterior wall of oropharynx Prepuce Prostate gland Pylorus Pyriform sinus Rectosigmoid junction Rectum NOS Renal pelvis Reticuloendothelial system NOS Retina Retromolar area Retroperitoneum Rib sternum clavicle and associated joints Round ligament Scrotum NOS Short bones of lower limb and associated joints Short bones of upper limb and associated joints Sigmoid colon Skin of lip NOS skin of lower limb and hip Skin of other and unspecified parts of face Skin of scalp and neck Skin of trunk skin of upper limb and shoulder skin NOS Small intestine NOS Soft palate NOS Specified parts of peritoneum Spermatic cord Sphenoid sinus Spinal cord Spinal meninges Spleen Splenic flexure of colon Stomach NOS Subglottis Sublingual gland Submandibular gland Superior wall of nasopharynx Supraglottis Tail of pancreas Temporal lobe Testis NOS Thoracic esophagus Thorax NOS Thymus Thyroid gland Tongue NOS Tonsil NOS Tonsillar fossa Tonsillar pillar Trachea Transverse colon Trigone of bladder Undescended testis unknown primary site Upper gum Upper limb NOS Upper lobe lung Upper respiratory tract NOS Upper third of esophagus Upper-inner quadrant of breast Upper-outer quadrant of breast Urachus Ureter Ureteric orifice Urethra Urinary system NOS Uterine adnexa Uterus NOS Uvula Vagina NOS Vallecula Ventral surface of tongue NOS Ventricle NOS Vertebral column Vestibule of mouth Vulva NOS Waldeyer ring Biliary tract NOS Cheek mucosa Clitoris Overlapping lesion of biliary tract unknown Not Reported
Progression or Recurrence Anatomic Site	Follow Up,Diagnosis	The text term used to describe the anatomic site of resection; biopsy; tissue or organ of biospecimen origin; progression or recurrent disease; treatment	False	Progression or Recurrence is "Yes - Progression or Recurrence"	String	Abdomen NOS Abdominal esophagus Accessory sinus NOS Acoustic nerve Adrenal gland NOS Ampulla of Vater Anal canal Anterior 2/3 of tongue NOS Anterior floor of mouth Anterior mediastinum Anterior surface of epiglottis Anterior wall of bladder Anterior wall of nasopharynx Anus NOS Aortic body and other paraganglia Appendix Ascending colon Autonomic nervous system NOS Axillary tail of breast Base of tongue NOS Bladder neck Bladder NOS Blood Body of pancreas Body of penis Body of stomach Bone marrow Bone of limb NOS Bone NOS Bones of skull and face and associated joints Border of tongue Brain stem Brain NOS Branchial cleft Breast NOS Broad ligament Cardia NOS Carotid body Cauda equina Cecum Central portion of breast Cerebellum NOS Cerebral meninges Cerebrum Cervical esophagus Cervix uteri Choroid Ciliary body Cloacogenic zone Colon NOS Commissure of lip Conjunctiva Connective subcutaneous and other soft tissues of abdomen Connective subcutaneous and other soft tissues of head face and neck Connective subcutaneous and other soft tissues of lower limb and hip Connective subcutaneous and other soft tissues of pelvis Connective subcutaneous and other soft tissues of thorax Connective subcutaneous and other soft tissues of trunk NOS Connective subcutaneous and other soft tissues of upper limb and shoulder Connective subcutaneous and other soft tissues NOS Cornea NOS Corpus uteri Cortex of adrenal gland Cranial nerve NOS Craniopharyngeal duct Descended testis Descending colon Dome of bladder Dorsal surface of tongue NOS Duodenum Endocervix Endocrine gland NOS Endometrium Epididymis Esophagus NOS Ethmoid sinus Exocervix External ear External lip NOS External lower lip External upper lip Extrahepatic bile duct Eye NOS Eyelid Fallopian tube Female genital tract NOS Floor of mouth NOS Frontal lobe Frontal sinus Fundus of stomach Fundus uteri Gallbladder Gastric antrum Gastrointestinal tract NOS Glans penis Glottis Greater curvature of stomach NOS Gum NOS Hard palate Head of pancreas Head face or neck NOS Heart Hematopoietic system NOS Hepatic flexure of colon Hypopharyngeal aspect of aryepiglottic fold Hypopharynx NOS Ileum Ill-defined sites within respiratory system Intestinal tract NOS Intra-abdominal lymph nodes Intrahepatic bile duct Intrathoracic lymph nodes Islets of Langerhans Isthmus uteri Jejunum Kidney NOS Labium majus Labium minus Lacrimal gland Laryngeal cartilage Larynx NOS Lateral floor of mouth Lateral wall of bladder Lateral wall of nasopharynx Lateral wall of oropharynx Lesser curvature of stomach NOS Lingual tonsil Lip NOS Liver Long bones of lower limb and associated joints Long bones of upper limb scapula and associated joints Lower gum Lower limb NOS Lower lobe lung Lower third of esophagus Lower-inner quadrant of breast Lower-outer quadrant of breast Lung NOS Lymph node NOS Lymph nodes of axilla or arm Lymph nodes of head face and neck Lymph nodes of inguinal region or leg Lymph nodes of multiple regions Main bronchus Major salivary gland NOS Male genital organs NOS Mandible Maxillary sinus Meckel diverticulum Mediastinum NOS Medulla of adrenal gland Meninges NOS Middle ear Middle lobe lung Middle third of esophagus Mouth NOS Mucosa of lip NOS Mucosa of lower lip Mucosa of upper lip Myometrium Nasal cavity Nasopharynx NOS Nervous system NOS Nipple Occipital lobe Olfactory nerve Optic nerve Orbit NOS Oropharynx NOS Other ill-defined sites Other specified parts of female genital organs Other specified parts of male genital organs Other specified parts of pancreas Ovary Overlapping lesion of accessory sinuses Overlapping lesion of bladder Overlapping lesion of bones joints and articular cartilage Overlapping lesion of bones joints and articular cartilage of limbs Overlapping lesion of brain Overlapping lesion of brain and central nervous system Overlapping lesion of breast Overlapping lesion of cervix uteri Overlapping lesion of colon Overlapping lesion of connective subcutaneous and other soft tissues Overlapping lesion of corpus uteri Overlapping lesion of digestive system Overlapping lesion of endocrine glands and related structures Overlapping lesion of esophagus Overlapping lesion of eye and adnexa Overlapping lesion of female genital organs Overlapping lesion of floor of mouth Overlapping lesion of heart mediastinum and pleura Overlapping lesion of hypopharynx Overlapping lesion of ill-defined sites Overlapping lesion of larynx Overlapping lesion of lip Overlapping lesion of lip oral cavity and pharynx Overlapping lesion of lung Overlapping lesion of major salivary glands Overlapping lesion of male genital organs Overlapping lesion of nasopharynx Overlapping lesion of other and unspecified parts of mouth Overlapping lesion of palate Overlapping lesion of pancreas Overlapping lesion of penis Overlapping lesion of peripheral nerves and autonomic nervous system Overlapping lesion of rectum anus and anal canal Overlapping lesion of respiratory system and intrathoracic organs Overlapping lesion of retroperitoneum and peritoneum Overlapping lesion of skin Overlapping lesion of small intestine Overlapping lesion of stomach Overlapping lesion of tongue Overlapping lesion of tonsil Overlapping lesion of urinary organs Overlapping lesion of vulva Overlapping lesions of oropharynx Palate NOS Pancreas NOS Pancreatic duct Parametrium Parathyroid gland Paraurethral gland Parietal lobe Parotid gland Pelvic bones sacrum coccyx and associated joints Pelvic lymph nodes Pelvis NOS Penis NOS Peripheral nerves and autonomic nervous system of abdomen Peripheral nerves and autonomic nervous system of head face and neck Peripheral nerves and autonomic nervous system of lower limb and hip Peripheral nerves and autonomic nervous system of pelvis Peripheral nerves and autonomic nervous system of thorax Peripheral nerves and autonomic nervous system of trunk NOS Peripheral nerves and autonomic nervous system of upper limb and shoulder Peritoneum NOS Pharynx NOS Pineal gland Pituitary gland Placenta Pleura NOS Postcricoid region Posterior mediastinum Posterior wall of bladder Posterior wall of hypopharynx Posterior wall of nasopharynx Posterior wall of oropharynx Prepuce Prostate gland Pylorus Pyriform sinus Rectosigmoid junction Rectum NOS Renal pelvis Reticuloendothelial system NOS Retina Retromolar area Retroperitoneum Rib sternum clavicle and associated joints Round ligament Scrotum NOS Short bones of lower limb and associated joints Short bones of upper limb and associated joints Sigmoid colon Skin of lip NOS skin of lower limb and hip Skin of other and unspecified parts of face Skin of scalp and neck Skin of trunk skin of upper limb and shoulder skin NOS Small intestine NOS Soft palate NOS Specified parts of peritoneum Spermatic cord Sphenoid sinus Spinal cord Spinal meninges Spleen Splenic flexure of colon Stomach NOS Subglottis Sublingual gland Submandibular gland Superior wall of nasopharynx Supraglottis Tail of pancreas Temporal lobe Testis NOS Thoracic esophagus Thorax NOS Thymus Thyroid gland Tongue NOS Tonsil NOS Tonsillar fossa Tonsillar pillar Trachea Transverse colon Trigone of bladder Undescended testis unknown primary site Upper gum Upper limb NOS Upper lobe lung Upper respiratory tract NOS Upper third of esophagus Upper-inner quadrant of breast Upper-outer quadrant of breast Urachus Ureter Ureteric orifice Urethra Urinary system NOS Uterine adnexa Uterus NOS Uvula Vagina NOS Vallecula Ventral surface of tongue NOS Ventricle NOS Vertebral column Vestibule of mouth Vulva NOS Waldeyer ring Biliary tract NOS Cheek mucosa Clitoris Overlapping lesion of biliary tract unknown Not Reported
Timepoint Label	Molecular Test,Clinical Data Tier 2,Acute Lymphoblastic Leukemia Tier 3,Breast Cancer Tier 3,Colorectal Cancer Tier 3,Lung Cancer Tier 3,Melanoma Tier 3,Ovarian Cancer Tier 3,Pancreatic Cancer Tier 3,Prostate Cancer Tier 3,Sarcoma Tier 3	Label to identify the time point at which the clinical data or biospecimen was obtained (e.g. Baseline, End of Treatment, Overall survival, Final). NO PHI/PII INFORMATION IS ALLOWED.	True		String	
Stop Days from Index	Molecular Test,Clinical Data Tier 2,Acute Lymphoblastic Leukemia Tier 3,Breast Cancer Tier 3,Colorectal Cancer Tier 3,Lung Cancer Tier 3,Melanoma Tier 3,Ovarian Cancer Tier 3,Pancreatic Cancer Tier 3,Prostate Cancer Tier 3,Sarcoma Tier 3	Number of days from the date of birth (index date) to the end date of the event (e.g. exposure to environmental factor, treatment start, etc.). Note: if the event occurs at a single time point, e.g. a diagnosis or a lab test, the values for this column is 'Not Applicable'	False		String	
Gene Symbol	Molecular Test	The text term used to describe a gene targeted or included in molecular analysis. For rearrangements, this is should be used to represent the reference gene. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	True		String	
Molecular Analysis Method	Molecular Test	The text term used to describe the method used for molecular analysis. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	True		String	Comparative Genomic Hybridization Cytogenetics NOS FISH Flow Cytometry IHC ISH Karyotype Microarray Microsatellite Analysis Nuclear Staining Other RNA Sequencing RT-PCR Sequencing NOS Southern Blotting Targeted Sequencing WGS WXS unknown Not Reported Not Applicable
Test Result	Molecular Test	The text term used to describe the result of the molecular test. If the test result was a numeric value see test_value. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	True		String	Abnormal NOS Copy Number Reported Equivocal High Intermediate Loss of Expression Low negative Normal Overexpressed positive Test Value Reported unknown Not Reported Not Applicable
AA Change	Molecular Test	Alphanumeric value used to describe the amino acid change for a specific genetic variant. Example: R116Q. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Antigen	Molecular Test	The text term used to describe an antigen included in molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	BCL6 CA-125 CA19-9 CCND1 CD10 CD117 CD138 CD14 CD15 CD19 CD20 CD22 CD23 CD25 CD3 CD30 CD33 CD34 CD45 CD5 CD56 CD7 CD79A CEA HLA-DR Mesothelin NSE Squamous Cell Carcinoma Antigen unknown Not Reported
Clinical Biospecimen Type	Molecular Test	The text term used to describe the biological material used for testing, diagnostic, treatment or research purposes. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	Blood Bone Marrow Buccal Mucosa Buffy Coat Cerebrospinal Fluid Connective Tissue Embryonic Fluid Embryonic Tissue Feces Granulocyte Muscle Tissue Nerve Tissue Peritoneal Fluid Plasma Pleural Fluid Saliva Serum Skin Soft Tissue Tissue NOS Uninvolved Tissue NOS Urine unknown Not Reported
Blood Test Normal Range Upper	Molecular Test	Numeric value used to describe the upper limit of the normal range used to describe a healthy individual at the institution where the test was completed.	False		String	
Blood Test Normal Range Lower	Molecular Test	Numeric value used to describe the lower limit of the normal range used to describe a healthy individual at the institution where the test was completed.	False		String	
Cell Count	Molecular Test	Numeric value used to describe the number of cells used for molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Chromosome	Molecular Test	The text term used to describe a chromosome targeted or included in molecular testing. If a specific genetic variant is being reported, this property can be used to capture the chromosome where that variant is located. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	chr1 chr2 chr3 chr4 chr5 chr6 chr7 chr8 chr9 chr10 chr11 chr12 chr13 chr14 chr15 chr16 chr17 chr18 chr19 chr20 chr21 chr22 chr23 chrM chrX chrY unknown Not Reported
Clonality	Molecular Test	The text term used to describe whether a genomic variant is related by descent from a single progenitor cell. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	Clonal Non-clonal
Copy Number	Molecular Test	Numeric value used to describe the number of times a section of the genome is repeated or copied within an insertion, duplication or deletion variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Cytoband	Molecular Test	Alphanumeric value used to describe the cytoband or chromosomal location targeted or included in molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the cytoband where the variant is located. Format: [chromosome][chromosome arm].[band+sub-bands]. Example: 17p13.1. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Exon	Molecular Test	Exon number targeted or included in a molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the exon where that variant is located. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Histone Family	Molecular Test	The text term used to describe the family, or classification of a group of basic proteins found in chromatin, called histones.	False		String	H1 H2A H2B H3 H4 unknown Not Reported
Histone Variant	Molecular Test	The text term used to describe a specific histone variants, which are proteins that substitute for the core canonical histones.	False		String	CENP-A H2A-Bbd H2A.X H2A.Z H2A.Z.1 H2A.Z.2 H2A.Z.2.2 H3.1 H3.2 H3.3 H3.5 H3.X H3.Y H3t (H3.4) mH2A mH2A.1 mH2A.2 unknown Not Reported
Intron	Molecular Test	Intron number targeted or included in molecular analysis. If a specific genetic variant is being reported, this property can be used to capture the intron where that variant is located.	False		String	
Laboratory Test	Molecular Test	The text term used to describe the medical testing used to diagnose, treat or further understand a patient's disease.	False		String	Absolute Neutrophil Albumin Alpha Fetoprotein B-cell genotyping Basophil Beta 2 Microglobulin Blood Urea Nitrogen C-Reactive Protein Calcium Cellularity Circulating Tumor Cells Creatinine Eosinophil Epstein-Barr Virus Glucose Hematocrit Hemoglobin HPV-E6/E7 Human Chorionic Gonadotropin Human Papillomavirus Immunoglobulin A Immunoglobulin G Immunoglobulin M Lactate Dehydrogenase Leukocytes Luteinizing Hormone Lymphoblasts Lymphocytes M Protein Metamyelocytes Myeloblasts Myelocytes Neutrophil Bands Platelets Prolymphocytes Promonocytes Promyelocytes Segmented Neutrophil Serum Free Immunoglobulin Light Chain Kappa Lambda NOS Testosterone Total Bilirubin Total Protein unknown Not Reported
Loci Abnormal Count	Molecular Test	Numeric value used to describe the number of loci determined to be abnormal.	False		String	
Loci Count	Molecular Test	Numeric value used to describe the number of loci tested.	False		String	
Locus	Molecular Test	Alphanumeric value used to describe the locus of a specific genetic variant. Example: NM_001126114.	False		String	
Mismatch Repair Mutation	Molecular Test	The yes/no/unknown indicator used to describe whether the mutation included in molecular testing was known to have an affect on the mismatch repair process. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	yes no unknown Not Reported
Molecular Consequence	Molecular Test	The text term used to describe the molecular consequence of genetic variation. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	3 Prime UTR Variant 5 Prime UTR Variant Coding Sequence Variant Downstream Gene Variant Feature Elongation Feature Truncation Frameshift Variant Incomplete Terminal Codon Variant Inframe Deletion Inframe Insertion Intergenic Variant Intron Variant Mature miRNA Variant Missense Variant NMD Transcript Variant Non-coding Transcript Exon Variant Non-coding Transcript Variant Protein Altering Variant Regulatory Region Ablation Regulatory Region Amplification Regulatory Region Variant Splice Acceptor Variant Splice Donor Variant Splice Region Variant Start Lost Stop Gain Stop Lost Stop Retained Variant Synonymous Variant TF Binding Site Variant TFBS Ablation TFBS Amplification Transcript Ablation Transcript Amplification Upstream Gene Variant
Pathogenicity	Molecular Test	The text used to describe a variant's level of involvement in the cause of the patient's disease according to the standards outlined by the American College of Medical Genetics and Genomics (ACMG).	False		String	Benign Likely Benign Likely Pathogenic Pathogenic Uncertain Significance
Ploidy	Molecular Test	Text term used to describe the number of sets of homologous chromosomes.	False		String	Aneuploid Diploid Hyperdiploid Hypodiploid Near Diploid Tetraploid unknown Not Reported
Second Exon	Molecular Test	The second exon number involved in molecular variation. If a specific genetic variant is being reported, this property can be used to capture the second exon where that variant is located. This property is typically used for a translocation where two different locations are involved in the variation.	False		String	
Second Gene Symbol	Molecular Test	The text term used to describe a secondary gene targeted or included in molecular analysis. For rearrangements, this is should represent the location of the variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Specialized Molecular Test	Molecular Test	Text term used to describe a specific test that is not covered in the list of molecular analysis methods. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Test Analyte Type	Molecular Test	The text term used to describe the type of analyte used for molecular testing. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	DNA mRNA miRNA Protein Analyte Total RNA unknown Not Reported
Test Units	Molecular Test	The text term used to describe the units of the test value for a molecular test. This property is used in conjunction with test_value. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Test Value	Molecular Test	The text term or numeric value used to describe a specific result of a molecular test. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here	False		String	
Transcript	Molecular Test	Alphanumeric value used to describe the transcript of a specific genetic variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	
Variant Origin	Molecular Test	The text term used to describe the biological origin of a specific genetic variant. Note: This node is meant to capture molecular tests that were completed clinically for the participant and only includes data from diagnostic array that was completed prior to research sequencing was done. Do not include data related to research assay outputs here.	False		String	Germline Somatic unknown
Variant Type	Molecular Test	The text term used to describe the type of genetic variation.	False		String	Alleles Amplification Chrimerism Conversion Deletion Deletion-Insertion Duplication Extension Gain Hypermethylation Insertion Inversion Loss Methylation Mosaicism Other Partial Methylation Rearrangement Repeated Sequences Splice Substitution Translocation unknown Not Reported
Zygosity	Molecular Test	The text term used to describe the zygosity of a specific genetic variant.	False		String	Heterozygous Hemizygous Homozygous Nullizygous unknown Not Reported
Mutational Signatures	Molecular Test,Clinical Data Tier 2	Mutational signatures identified in the patient, includes signatures linked to selected exogenous carcinogens, endogenous and enzymatic modification of DNA or defective DNA repair. Note: Include only outputs of tests that were completed clinically for the participant and only include data from a diagnostic array that was completed prior to research sequencing was done.	False		String	UV light induced mutations Alkylating Agents (Temozolomide) induced mutations Tobacco use associated mutations age of cancer diagnosis transcriptional strand bias microsatellite instability (additions and deletions) methylated CpG sequences mutagenesis(deamination of 5-methyl-cytosine) Activation Induced Deaminases (AID) associated mutations APOBEC enzymes associated mutations altered activity of the error-prone polymerase POLε (POLE) localized substitution hypermutation (kataegis) DNA MMR Deficiency Ig gene hypermutation Signature 1A Signature 1B Signature 2 Signature 3 Signature 4 Signature 5 Signature 6 Signature 7 Signature 8 Signature 9 Signature 10 Signature 11 Signature 12 Signature 13 Signature 14 Signature 15 Signature 16 Signature 17 Signature 18 Signature 19 Signature 20 Signature 21 Other Data not available Not Applicable Not Reported unknown
Mismatch Repair System Status	Molecular Test,Clinical Data Tier 2	The text that best describes the condition or state of MMR (mismatch repair system) in the patient	False		String	Mismatch repair deficiency MMRD Mismatch repair proficiency MMPP Microsatellite instability high MSIH Microsatellite stable MSS unknown or other
Lab Tests for MMR Status	Molecular Test,Clinical Data Tier 2	Laboratory tests used to evaluate the status of mismatch repair pathways	False		String	IHC staining for mismatch repair proteins PCR to evaluate microsatellite instability MLH1 promoter methylation analysis BRAF sequencing Other Not Applicable unknown
Treatment or Therapy	Therapy	A yes/no/unknown/not applicable indicator related to the administration of therapeutic agents received.	False		String	yes no unknown Not Reported
Treatment Type	Therapy	Text term that describes the kind of treatment administered.	False		String	Ablation Cryo Ablation Ethanol Injection Ablation Microwave Ablation NOS Ablation Radiofrequency Ablation Radiosurgical Ancillary Treatment Antiseizure Treatment Bisphosphonate Therapy Blinded Study Treatment unknown Brachytherapy High Dose Brachytherapy Low Dose Brachytherapy NOS Chemoembolization Chemoprotectant Chemotherapy Concurrent Chemoradiation Cryoablation Embolization Ethanol Injection Ablation External Beam Radiation Hormone Therapy I-131 Radiation Therapy Internal Radiation Immunotherapy (Including Vaccines) Isolated Limb Perfusion (ILP) Organ Transplantation Other Pharmaceutical Therapy NOS Pleurodesis Radiation 2D Conventional Radiation 3D Conformal Radiation Combination Radiation Cyberknife Radiation External Beam Radiation Implants Radiation Intensity-Modulated Radiotherapy Radiation Internal Radiation Proton Beam Radiation Radioisotope Radiation Stereotactic/Gamma Knife/SRS Radiation Systemic Radiation Therapy NOS Radioactive Iodine Therapy Radioembolization Radiosensitizing Agent Stem Cell Treatment Stem Cell Transplantation Autologous Stem Cell Transplantation Double Autologous Stem Cell Transplantation Allogeneic Stem Cell Transplantation Non-Myeloablative Stem Cell Transplantation Syngenic Stem Cell Transplantation Haploidentical Stem Cell Transplantation NOS Stereotactic Radiosurgery Steroid Therapy Surgery Targeted Molecular Therapy unknown Not Reported
Treatment Effect	Therapy	The text term used to describe the pathologic effect a treatment(s) had on the tumor.	False		String	Complete Necrosis (No Viable Tumor) Incomplete Necrosis (Viable Tumor Present) No Necrosis unknown Not Reported
Treatment Outcome	Therapy	Text term that describes the patient's final outcome after the treatment was administered.	False		String	Complete Response Mixed Response No Measurable Disease No Response Partial Response Persistent Disease Progressive Disease Stable Disease Treatment Ongoing Treatment Stopped Due to Toxicity Very Good Partial Response unknown Not Reported
Days to Treatment End	Therapy	Number of days between the date used for index and the date the treatment ended. If not applicable please enter 'Not Applicable'	False		String	
Days to Treatment Start	Therapy	Number of days between the date used for index and the date the treatment started. If not applicable please enter 'Not Applicable'	False		String	
Initial Disease Status	Therapy	The text term used to describe the status of the patient's malignancy when the treatment began.	False		String	Initial Diagnosis Progressive Disease Recurrent Disease Residual Disease unknown Not Reported
Regimen or Line of Therapy	Therapy	The text term used to describe the regimen or line of therapy.	False		String	
Therapeutic Agents	Therapy	Text identification of the individual agent(s) used as part of a treatment regimen.	False		String	
Treatment Intent Type	Therapy	Text term to identify the reason for the administration of a treatment regimen. [Manually-curated]	False		String	Adjuvant Cancer Control Cure Neoadjuvant Palliative Prevention unknown Not Reported
Chemo Concurrent to Radiation	Therapy	The text term used to describe whether the patient was receiving chemotherapy concurrent to radiation.	False		String	yes no unknown Not Reported
Number of Cycles	Therapy	The numeric value used to describe the number of cycles of a specific treatment or regimen the patient received.	False		String	
Reason Treatment Ended	Therapy	The text term used to describe the reason a specific treatment or regimen ended.	False		String	Adverse Therapy Event Course of Therapy Completed Death Disease Progression Other Withdrawal by Subject
Treatment Arm	Therapy	Text term used to describe the treatment arm assigned to a patient at the time eligibility is determined.	False		String	A081105 E4512 EA5142
Treatment Dose	Therapy	The numeric value used to describe the dose of an agent the patient received.	False		String	
Treatment Dose Units	Therapy	The text term used to describe the dose units of an agent the patient received.	False		String	cGy Gy
Treatment Effect Indicator	Therapy	The text term used to indicate whether the treatment had an effect on the patient.	False		String	yes no Not Reported unknown
Treatment Frequency	Therapy	The text term used to describe the frequency the patient received an agent or regimen.	False		String	Every Hour Five Times Daily Four Times Daily Three Times Daily Twice Daily Every 24 Hours Every Other Day Twice Weekly Once Weekly unknown Not Reported
Prior Sites of Radiation	Therapy,Clinical Data Tier 2	The anatomic location to which radiation treatment was administered to a patient prior to enrollment on a protocol.	False		String	Abdomen total Abdominal Wall Acetabulum Adenoid Adipose Adrenal Alveolar Ridge Amniotic Fluid Ampulla of Vater Anal Sphincter Ankle Anorectum Antecubital Fossa Antrum Anus Aorta Aortic Body Appendix Aqueous Fluid Arm Artery Ascending Colon Ascending Colon Hepatic Flexure Ascites Auditory Canal Autonomic Nervous System Axilla Back Bile Duct Bladder Blood Blood Vessel Body total Bone Bone Marrow Bone non-spine Bowel Brain Brain Stem Breast Broad Ligament Bronchiole Bronchus Brow Buccal Cavity Buccal Mucosa Buttock Calf Capillary Cardia Carina Carotid Artery Carotid Body Cartilage Cecum Cell-Line Central Nervous System Cerebellum Cerebral Cortex Cerebrospinal Fluid Cerebrum Cervical Spine Cervix Chest Chest Wall Chin Clavicle Clitoris Colon Colon Mucosa Only Common Duct Conjunctiva Connective Tissue Dermal Descending Colon Diaphragm Distant Site Duodenum Ear Ear Canal Ear Pinna (External) Elbow Endocrine Gland Epididymis Epidural Space Epitrochlear Esophagogastric Junction Esophagus Esophagus Mucosa Only Eye Fallopian Tube Femoral Artery Femoral Vein Femur Fibroblasts Fibula Finger Floor of Mouth Fluid Foot Forearm Forehead Foreskin Frontal Cortex Frontal Lobe Fundus of Stomach Gallbladder Ganglia Gastroesophageal Junction Gastrointestinal Tract Gastrointestinal Intestine Genitourinary NOS Groin Gum Hand Hard Palate Head Face Or Neck Nos Head and Neck Heart Hepatic Hepatic Duct Hepatic Vein Hilar Hip Hippocampus Humerus Hypopharynx Ileocecal Valve Ileum Ilium Index Finger Ischium Islet Cells Jaw Jejunum Joint Kidney Knee Lacrimal Gland Large Bowel Laryngopharynx Larynx Leg Leptomeninges Ligament Lip Liver Lumbar Spine Lung Lymph Node Lymph Node(s) Axilla Lymph Node(s) Cervical Lymph Node(s) Distant Lymph Node(s) Epitrochlear Lymph Node(s) Femoral Lymph Node(s) Hilar Lymph Node(s) Iliac-Common Lymph Node(s) Iliac-External Lymph Node(s) Inguinal Lymph Node(s) Internal Mammary Lymph Node(s) Mammary Lymph Node(s) Mediastinal Lymph Node(s) Mesenteric Lymph Node(s) Occipital Lymph Node(s) Paraaortic Lymph Node(s) Parotid Lymph Node(s) Pelvic Lymph Node(s) Popliteal Lymph Node(s) Regional Lymph Node(s) Retroperitoneal Lymph Node(s) Scalene Lymph Node(s) Splenic Lymph Node(s) Subclavicular Lymph Node(s) Submandibular Lymph Node(s) Supraclavicular Mandible Mantle Maxilla Mediastinal Soft Tissue Mediastinum Mesentery Mesothelium Middle Finger Mitochondria Muscle Nails Nasal Cavity Nasal Soft Tissue Nasopharynx Neck Nerve Nerve(s) Cranial Occipital Cortex Ocular Orbits Omentum Oral Cavity Oral Cavity Mucosa Only Oropharynx Other Ovary Palate Pancreas Parametrium Paraspinal Ganglion Parathyroid Parotid Gland Patella Pelvis Penis Pericardium Periorbital Soft Tissue Peritoneal Cavity Peritoneum Pharynx Pineal Pineal Gland Pituitary Gland Placenta Pleura Popliteal Fossa Pouch Primary Tumor Field Primary tumor site Prostate Prostate Bed Prostate Seminal Vesicles and Lymph Nodes Pylorus Rectosigmoid Junction Rectum Regional Site Retina Retro-Orbital Region Retroperitoneum Rib Ring Finger Round Ligament Sacrum Salivary Gland Scalp Scapula Sciatic Nerve Scrotum Seminal Vesicle Shoulder Sigmoid Colon Sinus Sinus(es) Maxillary Skeletal Muscle Skin Skin lower extremity local Skin total Skin trunk local Skin upper extremity local Skull Small Bowel Small Bowel Mucosa Only Small Finger Soft Tissue Spinal Column Spinal Cord Spine Spleen Splenic Flexure Sternum Stomach Stomach Mucosa Only Subcutaneous Tissue Synovium Temporal Cortex Tendon Testis Thigh Thoracic Spine Thorax Throat Thumb Thymus Thyroid Tibia Tongue Tonsil Tonsil (Pharyngeal) Trachea / Major Bronchi Transverse Colon Trunk Umbilical Cord unknown Ureter Urethra Urinary Tract Uterus Uvula Vagina Vas Deferens Vein Venous Vertebra Vulva White Blood Cells Wrist Not Reported
Immunosuppression	Therapy,Clinical Data Tier 2	The indicator that describes whether or not immunosuppressive therapy was administered.	False		String	yes no unknown Not Applicable Not Done
Concomitant Medication Received Type	Therapy,Clinical Data Tier 2	An enumerated list of the type of concomitant medication received by the patient.	False		String	Anticoagulant agents Anticonvulsant Antifungal Antiplatelet agents Antidepressants-Moderate CYP2D6 inhibitors Antidepressants-Strong CYP2D6 inhibitors Antidepressants-weak CYP2D2 inhibitors or non-inhibitors Anxiolytics or sedatives Aspirin Bisphosphonates for treatment/prevention of bone loss Corticosteroid COX-2 inhibitor Decadron Diabetes-Insulin Diabetes-Metformin containing agents Growth factor Intravaginal estrogen preparations Lipid-lowering drugs Non-prescription supplements for memory Non-prescription supplements for relief of hot flashes Non-steroidal anti-inflammatory agents Opioids Other Prescription medications for memory Prescription medications for relief of hot flashes Prophylactic antiplatelet therapy Tricyclic antidepressants Not Applicable unknown Not Reported
Education Level	Clinical Data Tier 2	Highest level of education that the patient completed (direct patient-derived information)	False		String	Bachelor's degree Doctoral degree or professional degree Grade school Graduate or professional degree High school graduate (including equivalency) Master's degree No formal education Not high school graduate Some college or associate degree Data not available
Country of Birth	Clinical Data Tier 2	Country where the patient was born.	False		String	Afghanistan Albania Algeria Andorra Angola Anguilla Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Brazil Brunei Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Colombia Comoros Congo Cook Islands Costa Rica Cote d'Ivoire Croatia Cuba Curacao Cyprus Czech Republic (Czechia) Democratic Republic of the Congo Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Eswatini Ethiopia Falkland Islands (Malvinas) Faroe Islands Federated States of Micronesia Fiji Finland France French Guiana French Polynesia Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Holy See Honduras Hong Kong Hungary Iceland India Indonesia Iran Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Kosovo Kuwait Kyrgyzstan Laos Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macau Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue North Korea North Macedonia Northern Mariana Islands Norway Oman Pakistan Palau Panama Papua New Guinea Paraguay Peru Philippines Poland Portugal Puerto Rico Qatar Reunion Romania Russia Rwanda Saint Helena Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Korea South Sudan Spain Sri Lanka State of Palestine Sudan Suriname Svalbard & Jan Mayen Islands Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela Vietnam Virgin Islands British Virgin Islands U.S. Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe unknown
Medically Underserved Area	Clinical Data Tier 2	Areas or populations designated by HRSA as having too few primary care providers, high infant mortality, high poverty or a high elderly population:  Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/ - enter the zip code in the main text field and use the associated county on the right side of the result field. Go to data.hrsa.gov website and select "Query Data". Pick the Medically Underserved Areas/Populations (MUA/P) data source in the step 1 menu and select "View Data". Enter the name of the county (_______ county) in the first "Service Area" column, adding the state in the 5th column may help direct you to the data.  If the designation type in the third column is "medically underserved area" enter "Yes" as the value. If the county generates a "No data available in table" enter "No" as the value.  A value of "Unknown" indicates that sufficient data was not available to look up the value.  If value is yes, complete the Medically_underserved_score data element.	False		String	Medically Underserved Area - Yes Medically Underserved Area - No Medically Underserved Area - Unknown
Rural vs Urban	Clinical Data Tier 2	Density of population in the county of residence, based on census data (updated last on 4/28/20). Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the associated county on the right side of the result field. Go to https://www2.census.gov/programs-surveys/acs/data/covid_19/Data_Profiles_for_HHS/050-County_By_State/. Select the dp02_XX.csv file where XX = the two letter abbreviation for the appropriate state. On row 166 find the total population for the appropriate county.  If the total population is <2,500 enter a value of "Rural Population"; if 2,500 - 50,000 enter a value of "Urban Cluster"; or if >50,000 enter "Urban Population"	False		String	Urban Population (population >50000) Urban Cluster (population 2500 - 50000) Rural Population (population <2500)
Cancer Incidence	Clinical Data Tier 2	Incidence of specific cancer type in a defined area (a number between 0 and 100). The rate of incident cases per population of 100,000 persons of a specific type of cancer as designated in the "primary_diagnosis" data element in the county where the patient resides, using the most recent 2013-2017 NCI Cancer Atlas derived data.  Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the asociated county on the right side of the result field. On the https://gis.cancer.gov/canceratlas/tableview/ website, choose "Incidence" from the Topic dropdown menu, state of interest from the Area menu, "All Races" from the Race menu, and the cancer type ("Both Sexes" when possible) from the Statistic menu. Find the county of interest and enter the numeric Age-Adjusted Rate per 100,000 as the value.	False		String	
Cancer Incidence Location	Clinical Data Tier 2	The county and state in which the patient lives and to which the cancer_incidence data correlates. Record as "County, State" as they appear in the incidence box from which the cancer_incidence data is obtained in the https://gis.cancer.gov/canceratlas/tableview/ website	False		String	
Specimen Blast Count Percentage Value	Acute Lymphoblastic Leukemia Tier 3	The value, in percent(%) of the medical procedure that involves testing a sample of blood for blast cells, immature (undifferentiated) cells during diagnosis	False		String	
NCI ALL Risk Group	Acute Lymphoblastic Leukemia Tier 3	The NCI risk group assigned to a patient at initial diagnosis with Acute Lymphoblastic Leukemia.	False		String	NCI High Risk NCI Standard Risk unknown
MRD ALL Diagnostic Sensitivity	Acute Lymphoblastic Leukemia Tier 3	The assay sensitivity results of a diagnostic assessment of Minimal Residual Disease in patients diagnosed with Acute Lymphoblastic Leukemia.	False		String	Optimal Suboptimal Indeterminate unknown
CNS Leukemia Status	Acute Lymphoblastic Leukemia Tier 3	The status of central nervous system leukemia at the time of diagnosis.	False		String	CNS 1 CNS 2 CNS 3 CNS 2a CNS 2b CNS 2c CNS 3a CNS 3b CNS 3c Not evaluated unknown
Breast Carcinoma Detection Method Type	Breast Cancer Tier 3	The means, manner of procedure, or systematic course of actions performed in order to discover or identify breast cancer.	False		String	Clinical Exam Data not available Nipple Discharge Other Screening Mammography Screening MRI Self exam unknown
Breast Carcinoma Histology Category	Breast Cancer Tier 3	Classification of the type of invasive breast carcinoma diagnosed based on histologic attributes.	False		String	Infiltrating ductal carcinoma Infiltrating lobular carcinoma Invasive mammary carcinoma NOS Invasive mixed ductal and lobular carcinoma Other
Invasive Lobular Breast Carcinoma Histologic Category	Breast Cancer Tier 3	The histologic subtype for an infiltrating lobular carcinoma of the breast.	False		String	Alveolar type Classical type Data not available Pleomorphic type unknown
Invasive Ductal Breast Carcinoma Histologic Category	Breast Cancer Tier 3	The histologic subtype for the most common type of invasive breast carcinoma.	False		String	Classical type Invasive carcinoma-type cannot be determined Invasive cribriform carcinoma Invasive micropapillary carcinoma Invasive papillary carcinoma Invasive tubular carcinoma Medullary carcinoma Mucinous carcinoma Tubulolobular carcinoma Other unknown Data not available
Breast Biopsy Procedure Finding Type	Breast Cancer Tier 3	Text term to describe the result of the examination of the breast tissue specimen or fluid as related to the presence and nature of disease.	False		String	Atypical hyperplasia DCIS LCIS Cancer No cancer Other
Breast Quadrant Site	Breast Cancer Tier 3	The breast quadrant or structure from which the breast tissue specimen was removed for microscopic examination.	False		String	Upper outer quadrant Lower outer quadrant Upper inner quadrant Lower inner quadrant Central Nipple unknown Data not available
Breast Cancer Assessment Tests	Breast Cancer Tier 3	Text term to identify assessment tests done in participants during diagnosis	False		String	Estrogen receptor IHC Progesterone receptor IHC HER2 IHC HER2 FISH-CISH HER2 FISH Other unknown Data not available
Breast Cancer Genomic Test Performed	Breast Cancer Tier 3	Text term that represents the name of the genomic test performed for breast cancer.	False		String	Oncotype MammaPrint Other Data not available unknown Not performed
Mammaprint Risk Group	Breast Cancer Tier 3	Text term that represents the risk group for breast cancer as determined by assessment of the MammaPrint test.	False		String	High risk Intermediate risk Low risk Data not available unknown
Oncotype Risk Group	Breast Cancer Tier 3	Text term that represents the risk group for breast cancer as determined by assessment of the Oncotype recurrence score.	False		String	High risk Intermediate risk Low risk Data not available unknown
Breast Carcinoma Estrogen Receptor Status	Breast Cancer Tier 3	Text term to represent the overall result of Estrogen Receptor (ER) testing in a participant with breast cancer	False		String	Borderline Equivocal Indeterminate negative Not Performed Performed but Not Available positive unknown
Breast Carcinoma Progesteroner Receptor Status	Breast Cancer Tier 3	Text term to represent the overall result of Progresterone Receptor (PR) testing in a participant with breast cancer	False		String	Borderline Equivocal Indeterminate negative Not Performed Performed but Not Available positive unknown
Breast Cancer Allred Estrogen Receptor Score	Breast Cancer Tier 3	The numeric Allred score, that is cell staining percentage plus intensity, to determine estrogen receptor status.	False		String	0 1 2 3 4 5 6 7 8 10 unknown
Prior Invasive Breast Disease	Breast Cancer Tier 3	Text term to indicate prior invasive breast condition in the participant	False		String	DCIS LCIS Invasive breast cancer (unrelated to the current cancer) Other unknown Data not available
Breast Carcinoma ER Status Percentage Value	Breast Cancer Tier 3	A numerical quantity measured or assigned or computed which captures the estrogen receptor level measured in a participant with breast cancer	False		String	
Breast Carcinoma PR Status Percentage Value	Breast Cancer Tier 3	A numerical quantity measured or assigned or computed which captures the progesterone receptor level measured in a participant with breast cancer	False		String	
HER2 Breast Carcinoma Copy Number Total	Breast Cancer Tier 3	Result of HER2 Copy Number testing (in a participant with breast cancer), expressed as a range of values.	False		String	
Breast Carcinoma Centromere 17 Copy Number	Breast Cancer Tier 3	Result of Centromere 17 testing in a sample or specimen of metastatic breast carcinoma, expressed as a range of values.	False		String	
Breast Carcinoma HER2 Centromere17 Copynumber Total	Breast Cancer Tier 3	Number of Cells Counted for HER2 & Centromere 17 Copy Numbers in a participant with breast cancer	False		String	
Breast Carcinoma HER2 Chromosome17 Ratio	Breast Cancer Tier 3	HER2 chromosome 17 ratio in participants with breast cancer	False		String	
Breast Carcinoma Surgical Procedure Name	Breast Cancer Tier 3	Text name of a surgical procedure performed for a person with a diagnosis of breast cancer	False		String	Lumpectomy Radical mastectomy Modified radical mastectomy Other Partial mastectomy Re-excision Simple mastectomy Surgery not performed unknown
Breast Carcinoma HER2 Ratio Diagnosis	Breast Cancer Tier 3	HER2 ratio of the participant at diagnosis	False		String	
Breast Carcinoma HER2 Status	Breast Cancer Tier 3	Text term to signify the result of the medical procedure that involves testing a sample of blood or tissue for HER2 in a participant with breast cancer	False		String	positive negative Amplified Non-amplified Equivocal Indeterminate Not Performed unknown
Hormone Therapy Breast Cancer Prevention Indicator	Breast Cancer Tier 3	Did the patient receive hormonal therapy for prevention of breast cancer?	False		String	yes no unknown Not Applicable
Breast Carcinoma ER Staining Intensity	Breast Cancer Tier 3	Text term to indicate the ER staining intensity on pathology assessment in a participant with breast cancer	False		String	Strong Moderate Weak Weak-Moderate Moderate-Strong Weak-Strong Other unknown
Breast Carcinoma PR Staining Intensity	Breast Cancer Tier 3	Text term to indicate the PR staining intensity on pathology assessment in a participant with breast cancer	False		String	Strong Moderate Weak Weak-Moderate Moderate-Strong Weak-Strong Other unknown
Oncotype Score	Breast Cancer Tier 3	OncotypeDX recurrence score	False		String	
Breast Imaging Performed Type	Breast Cancer Tier 3	The kind of technology or method performed for screening, diagnosis, surgical procedures or therapy that aids in the visualization of the breast(s).	False		String	Mammogram Ultrasound MRI PET/CT CT Multiple imaging modalities unknown Data not available
Multifocal Breast Carcinoma Present Indicator	Breast Cancer Tier 3	A response to indicate if there is breast cancer characterized by the presence of multiple cancerous tumors that originate from the same clone and usually located in the same quadrant of the breast.	False		String	yes no unknown Data not available
Multicentric Breast Carcinoma Present Indicator	Breast Cancer Tier 3	A response to indicate if there is breast cancer characterized by the presence of multiple cancerous tumors that originate from different clones and usually located in different quadrants of the breast.	False		String	yes no unknown Data not available
BIRADS Mammography Breast Density Category	Breast Cancer Tier 3	The category that describes the relative amount of different tissues present in the breast on a mammogram based on the updated 2015 edition of the American College of Radiology's Breast Imaging Reporting and Data System (BI-RADS) reporting guidelines.	False		String	Predominantly fatty Scattered fibroglandular densities Heterogeneously dense Extremely dense unknown Data not available
Colorectal Cancer Detection Method Type	Colorectal Cancer Tier 3	The means, manner of procedure, or systematic course of actions performed in order to discover or identify colorectal cancer	False		String	Fecal occult blood test Sigmoidoscopy Colonoscopy Virtual colonoscopy DNA stool test Other unknown Data not available
History of Prior Colon Polyps	Colorectal Cancer Tier 3	Yes/No indicator to describe if the subject had a previous history of colon polyps as noted in the history/physical or previous endoscopic report (s).	False		String	yes no Not Applicable unknown
Family Colon Cancer History Indicator	Colorectal Cancer Tier 3	The indicator to designate if any first degree relative has a history of colorectal cancer.	False		String	yes no Not Applicable unknown
Family Medical History Colorectal Polyp Diagnosis	Colorectal Cancer Tier 3	A yes/no/unknown/not applicable indicator related to family medical history diagnosis of polypoid lesion that arises from the colon or rectum and protrudes into the lumen.	False		String	yes no Not Applicable unknown
Immediate Family History Endometrial Cancer	Colorectal Cancer Tier 3	Text that describes the age at which the family member was diagnosed with endometrial or uterine cancer in relationship to their 50th birthday.	False		String	Before age 50 Not before age 50 unknown Not Applicable
Immediate Family History Ovarian Cancer	Colorectal Cancer Tier 3	Text that describes the age at which the family member was diagnosed with ovarian cancer in relationship to their 50th birthday.	False		String	Before age 50 Not before age 50 unknown Not Applicable
Patient Inflammatory Bowel Disease Personal Medica History	Colorectal Cancer Tier 3	The indicator for patient's personal medical history of inflammatory bowel disease (chronic, non-specific disorders of unknown etiology, including Crohn disease and ulcerative colitis).	False		String	Yes - Crohn's disease Yes - Ulcerative colitis no unknown Not Applicable
Patient Colonoscopy Performed Indicator	Colorectal Cancer Tier 3	The yes/no indicator that records if the subject has undergone a previous colonoscopy.	False		String	yes no Not Applicable unknown
Colorectal Cancer Tumor Border Configuration	Colorectal Cancer Tier 3	The description of the border configuration of a colorectal tumor at pathologic assessment.	False		String	Indeterminate Infiltrating Other Pushing Not Applicable
MLH1 Promoter Methylation Status	Colorectal Cancer Tier 3	Text term to define the status of promoter methylation for the MLH1 gene. Note: MLH1 gene is commonly associated with hereditary nonpolyposis colorectal cancer. Testing for methylation of the MLH1 promoter can help distinguish sporadic from inherited cancers.	False		String	Absent Indeterminate Not Assessed Present
Colorectal Cancer KRAS Indicator	Colorectal Cancer Tier 3	The yes/no/not applicable indicator that describes if patient has diagnosis of colorectal cancer with known KRAS.	False		String	yes no unknown Not Applicable
Colon Polyp Occurence Indicator	Colorectal Cancer Tier 3	Yes/No indicator to describe if the subject had a previous history of colon polyps as noted in the history/physical or previous endoscopic report (s).	False		String	yes no unknown Not Applicable
Family History Colorectal Polyp	Colorectal Cancer Tier 3	A yes/no/unknown/not applicable indicator related to family medical history diagnosis of polypoid lesion that arises from the colon or rectum and protrudes into the lumen.	False		String	yes no unknown Not Applicable
Colorectal Polyp New Indicator	Colorectal Cancer Tier 3	A yes/no response to a question that asks whether any new polyps greater or equal to two millimeter were identified.	False		String	yes no unknown Not Applicable
Colorectal Polyp Shape	Colorectal Cancer Tier 3	Shape of polyp identified in the participant	False		String	Pedunculated Sessile Flat Not stated Not Applicable
Size of Polyp Removed	Colorectal Cancer Tier 3	Size of the polyp removed in cm	False		String	
Colorectal Polyp Count	Colorectal Cancer Tier 3	The total number of polyps detected	False		String	
Colorectal Polyp Type	Colorectal Cancer Tier 3	Type of polyp found in the participant	False		String	Adenoma Hyperplastic Mixed Papillomatous Normal Cancer Other unknown
Colorectal Polyp Adenoma Type	Colorectal Cancer Tier 3	Type of adenoma associated with the polyp	False		String	Tubular Villous Tubulovillous Sessile serrated Traditional serrated Serrated not specified Not stated Not Applicable
Lung Cancer Detection Method Type	Lung Cancer Tier 3	The means, manner of procedure, or systematic course of actions performed in order to discover or identify lung cancer	False		String	Low Dose Computed Tomography (LDCT) Chest X-ray Chest CT unknown Data not available Other
Lung Cancer Participant Procedure History	Lung Cancer Tier 3	Text name of a surgical or operative procedure used in a natural history protocol of a lung cancer participant.	False		String	Lobectomy Bilateral Lobectomy Left Lobectomy Right Lung Wedge Resection Bilateral Lung Wedge Resection Left Lung Wedge Resection Multiple Lung Wedge Resection Right Pneumonectomy Left Pneumonectomy Right Endobronchial biopsy Mediastinoscopy VATS Sclerosis Brain resection Segmentectomy unknown Other Not Reported
Lung Adjacent Histology Type	Lung Cancer Tier 3	The type of morphologic characteristics observed by microscope in the tissue next to a benign or malignant tissue growth	False		String	Lung adenocarcinoma Adenosquamous carcinoma Carcinoid tumor and lung atypical carcinoid tumor Lung adenocarcinoma in situ Large cell lung carcinoma Large cell neuroendocrine carcinoma Lung lymphoepithelioma-like carcinoma Bronchioalveolar carcinoma Thoracic NUT carcinoma Sarcomatoid carcinoma Small cell lung carcinoma Squamous cell lung carcinoma Lung squamous cell carcinoma in situ Other unknown Not Reported
Lung Tumor Location Anatomic Site	Lung Cancer Tier 3	Anatomic location of the tumor inside the lung	False		String	Main carina Left Right unknown Not Reported
Lung Tumor Lobe Bronchial Location	Lung Cancer Tier 3	Anatomic lobe and bronchial location of the tumor inside the lung	False		String	Upper lobe Middle lobe Lower lobe Stump Bronchus unknown Not Reported
Current Lung Cancer Symptoms	Lung Cancer Tier 3	Reported lung cancer related symptoms person is currently experiencing	False		String	asbestosis productive cough non-productive cough wheezing rhonci crackles hemoptysis dyspnea unexplained weight loss unexplained loss of energy/fatigue chest pain or discomfort dysphagia pneumonia hoarseness/laryngitis/vocal cord inflammation air entry decreased/fair/poor/diminished fair/poor aeration shallow inspiration breath sounds coarse/diminished dullness to percussion abnormal breath sounds clear lungs to auscultation or percussion unlabored/normal breathing cold symptoms/flu/sinus/nasal congestion sinus pain/infection finger clubbing no evidence of lung cancer recurrence patient is NED oxygen supplemental-portable O2 at night or continuous prolonged expiration-long/forced expiratory phase Other unknown Not Reported
Lung Topography	Lung Cancer Tier 3	Lung PCA specific topography (not covered in previous tiers)	False		String	MC-Carina between right and left lungs (main carina) TR -Trachea (airway wall between tracheo-esophageal bifurcation and main carina) Carina NOS (Carina not otherwise specified) LUDB-Carina between the lingula and upper division left upper lobe Carina between LUDB orifice and lingula orifice LUDB-orifice airway wall between LUDB and LB3(LB1+2 carinae) Lingula orifice airway wall between LUDB and LB4/5 carinae RMB-Right mainstem bronchus(airway wall between MC & RUL carina) LMB-Left mainstem bronchus(airway wall between MC & LUL carina) RL NOS (Right lung not otherwise specified) RB1/2 - Carina between apical and posterior segments right upper lobe (Carina between RB1 orifice and RB2 orifice) RB6A/B - Carina between apical and lateral subsegments superior segment RLL RB6A/C - Carina between apical and medial subsegments superior segment RLL RB6B/C - Carina between medial and lateral subsegments superior segment RLL RB7A/B - Carina between medial and lateral subsegments medial basal segment RLL RB8/9 - Carina between anterior and lateral segments RLL (Carina between RB8 orifice and RB9 orifice) RB8A/B - Carina between medial and lateral subsegments anterior segment RLL RB9/10 - Carina between lateral and posterior segments RLL RB9A/B - Carina between medial and lateral subsegments lateral segment RLL RB10A/B - Carina between medial and lateral subsegments posterior segment RLL RB10A/C - Carina between medial and apical subsegments posterior segment RLL RB1A/B - Carina between medial and lateral subsegments apical segment RUL RB10B/C - Carina between medial and lateral subsegments posterior segment RLL RB6 - Carina of superior segment RLL (Carina between RB6 orifice and lower portion of RLL orifice) RB6 orifice Airway wall between RB6 and RB6A/B/C carinae Bronchus Intermedius Bronchus (airway wall) between right upper and right middle lobes RB1/3 - Carina between apical and anterior segments RUL (Carina between RB1 orifice and RB3 orifice) RB2/3 - Carina between anterior and posterior segments RUL (Carina between RB2 orifice and RB3 orifice) RB2A/B - Carina between the medial and lateral subsegments of the posterior segment (RUL) RB3A/B - Carina between the medial and lateral subsegments of the anterior segment RUL RB4/5 - Carina between the lateral and medial segments right middle lobe (Carina between RB4 orifice and RB5 orifice) RB4A/B - Carina between the medial and lateral subsegments of the lateral segment of the right middle lobe RB5A/B - Carina between the medial and lateral subsegments of the medial segment of the right middle lobe RUL Carinae between RUL orifice and bronchus intermedius RUL orifice Airway wall between RUL and RB1/RB2/RB3 RB1 orifice Apical segment - right upper lobe(airway wall between RB1 and RB1A/B carinae) RB2 orifice Posterior segment - right upper lobe(airway wall between RB2 and RB2A/B carinae) RB3 orifice Anterior segment - right upper lobe(airway wall between RB3 and RB3A/B carinae) RML - Carina between RML orifice and RLL orifice RML orifice Airway wall between RML and RB4/5 RB4 orifice Lateral segment right middle lobe (airway wall between RB4 and RB4A/B carinae) RB5 orifice Medial segment right middle lobe (airway wall between RB5 and RB5A/B carinae) RLL orifice Airway wall between RML and RB6-10 carinae RB7 Medial basal segment right lower lobe (Carina at RB7 orifice takeoff from RLL orifice) RB7 orifice Airway wall between RB7 and RB7A/B carinae RB8 orifice Anterior segment right lower lobe(airway wall between RB8 and RB8A/B carinae) RB9 orifice Lateral segment right lower lobe(airway wall between RB9 and RB9A/B carinae) RB10 Posterior segment right lower lobe (Carina at RB10 orifice takeoff from RLL orifice) RB10 orifice Airway wall between RB10 and RB10A/B carinae LL NOS (Left lung not otherwise specified) LB1/2  Carina between apical and posterior segment left upper lobe (Carina between LB1 orifice and LB2 orifice) LB4/5  Carina between superior and inferior segment lingula (Carina between LB4 orifice and LB5 orifice) LB4A/B  Carina between medial and lateral subsegments superior segment lingula LB5A/B  Carina between the medial and lateral subsegments inferior segment lingula LB6A/B  Carina between the superior and lateral subsegments superior segment LLL LB6A/C  Carina between the superior and medial subsegments of superior segment LLL LB6B/C  Carina between the medial and lateral subsegments of the superior segment LLL LB8/9  Carina between the anterior and lateral segments LLL (Carina between LB8 orifice and LB9 orifice) LB8A/B  Carina between the medial and lateral subsegments of the anterior segment LLL LB9/10  Carina between the lateral and posterior segments LLL (Carina between LB9 orifice and LB10 orifice) LB9A/B  Carina between the medial and lateral subsegments of the lateral segment LLL LB1A/B  Carina between the lateral and medial subsegments of the apical segment of the LUL LB10A/B  Carina between the apical and lateral subsegments of the posterior segment of the LLL LB10A/C  Carina between the apical and medial segments of the posterior segment of the LLL LB10B/C  Carina between the medial and lateral subsegments of the posterior segment of the LLL LB1+2 orifice  The apico-posterior segment of the left upper lobe (airway wall between LB1+2/3 carina and LB1 or LB2) LB6  The superior segment of the left lower lobe (Carina between LB6 orifice and lower portion of LLL orifice) LB6 orifice Airway wall between LB6 and LB6A/B carinae LB1A/C  Carina between the apical and lateral subsegments of the apical segment left upper lobe LB1B/C  Carina between the medial and lateral subsegments of the apical segment of the left upper lobe LB2A/B  Carina between the apical and lateral subsegments of the posterior segment of the left upper lobe LB2A/C  Carina between the apical and medial subsegments of the posterior segment of the left upper lobe LB2B/C  Carina between the medial and lateral subsegments of the posterior segment left upper lobe LB1+2/3  Carina between the apico-posterior and anterior segments of the left upper lobe (Carina between LB1+2 orifice and LB3 orifice) LB3A/B Carina between the apical and lateral subsegments of the anterior segment of the left upper lobe LUL Carina between the LUL orifice and LLL orifice (airways) LUL orifice Airway wall between LUL and LUDB LB3 orifice Anterior segment left upper lobe(airway wall between LB3 and LB3A/B carinae) LB4 orifice Superior segment lingula(airway wall between LB4 and LB4A/B carinae) LB5 orifice Inferior segment lingula(airway wall between LB5 and LB5A/B carinae) LLL orifice Airway wall between LUL carina and LB6-10 carinae LB9 orifice Lateral segment left lower lobe(airway wall between LB9 and LB9A/B carinae) LB8 orifice Anterior segment left lower lobe(airway wall between LB8 and LB8A/B carinae) LB10 orifice  Posterior segment left lower lobe(airway wall between LB10 and LB10A/B carinae) Other unknown Not Reported
Lung Cancer Harboring Genomic Aberrations	Lung Cancer Tier 3	Genomic aberrations in participants with lung cancer (specific lung cancer associated gene mutations not covered in Tiers 1 and 2)	False		String	G12A KRAS mutation G12C KRAS mutation G12D KRAS mutation G12R KRAS mutation G12S KRAS mutation G12V KRAS mutation G13D KRAS mutation G13R KRAS mutation G13C KRAS mutation G13A KRAS mutation G13V KRAS mutation Q61L KRAS mutation Q61H KRAS mutation A146T KRAS mutation G719X EGFR mutation T790M EGFR mutation C797S EGFR mutation L858R EGFR mutation L861Q EGFR mutation Exon 19 deletion Exon 20 insertion EML4-ALK translocation-variant 1 EML4-ALK translocation-variant 2 EML4-ALK translocation-variant 3 EML4-ALK translocation-variant 4 EML4-ALK translocation-variant 5 V600E BRAF mutation V600D BRAF mutation V600K BRAF mutation V600R BRAF mutation K601E BRAF mutation D963 splice MET mutation D1010N MET mutation D1010 splice MET mutation Intron 13 mutation Intron 14 mutation Exon 14 mutation Exon 14 deletion Other unknown Not Reported
Cutaneous Melanoma Tumor Infiltrating Lymphocytes	Melanoma Tier 3	Description of degree of lymphocytic infiltration surrounding and disrupting tumor cells of the vertical growth phase in a cutaneous melanoma.	False		String	Absent Brisk Nonbrisk unknown
Cutaneous Melanoma Tumor Regression Range	Melanoma Tier 3	Description of the degree to which tumor cells are replaced by lymphocytic inflammation with or without dermal melanophages and fibrosis._Range; the difference between the lowest and highest numerical values.	False		String	Absent Present involving 75% or more Present involving less than 75% unknown
Melanoma Specimen Clark Level Value	Melanoma Tier 3	Definition of the Clark level or depth of involvement of a melanoma in the skin or a specimen.	False		String	I II III IV V No Source Documentation unknown
Cutaneous Melanoma Surgical Margins	Melanoma Tier 3	Text term to indicate presence of tumor at resection margins	False		String	positive negative unknown Not Reported
Melanoma Lesion Size	Melanoma Tier 3	Diameter of lesion determined on skin examination (pre-bx), in mm	False		String	
History of Atypical Nevi	Melanoma Tier 3	Patient has a history of atypical nevi	False		String	Yes (more than 50) Yes (less than 50) no unknown Not Reported
Fitzpatrick Skin Tone	Melanoma Tier 3	The Fitzpatrick classification of skin phototype	False		String	I II III IV V VI unknown Not Reported
History of Chronic UV Exposure	Melanoma Tier 3	History of chronic UV exposure	False		String	Outdoor occupational Outdoor recreational Therapeutic None Not Reported
History of Blistering Sunburn	Melanoma Tier 3	Patient has history of blistering sunburn	False		String	yes no unknown Not Reported
History of Tanning Bed Use	Melanoma Tier 3	History of tanning bed use of the patient	False		String	Never Less than 10 times 10-50 times 50-100 times More than 100 times Not Reported
Immediate Family History Melanoma	Melanoma Tier 3	Text that describes the age at which the family member was diagnosed with melanoma skin cancer in relationship to their 50th birthday.	False		String	Before age 50 Not before age 50 unknown
Melanoma Biopsy Resection Sites	Melanoma Tier 3	Biopsy resection sites specific to melanoma (not covered in Tiers 1 and 2)	False		String	skin of scalp skin of eye lid skin of nose skin of lip skin of ear skin of neck skin of other parts of face skin of chest skin of back skin of abdomen skin of trunk-other skin of breast skin of upper limb and shoulder skin of palm skin of lower limb and hip skin of sole skin of penis skin of scrotum skin of vulva skin other skin NOS Not Reported
Cutaneous Melanoma Ulceration	Melanoma Tier 3	Description of extent of disruption to the surface of the skin caused by the cutaneous melanoma.	False		String	Absent Present unknown Not Reported
Cutaneous Melanoma Additional Findings	Melanoma Tier 3	Significant pathologic finding present in addition to the cutaneous melanoma.	False		String	Actinic Keratosis Nevus Remnant Solar Elastosis Fibrosing Regression Nesting Melanoma Pagetoid Spread Vascular Proliferation Other unknown Not Applicable
Ovarian Cancer Histologic Subtype	Ovarian Cancer Tier 3	Text term to describe the histological subtype of ovarian cancer in the participant	False		String	High-grade serous Low-grade serous High-grade endometrioid Low-grade endometrioid Clear cell Mucinous Sex-cord stromal Germ cell Other unknown Data not available
Ovarian Cancer Surgical Outcome	Ovarian Cancer Tier 3	Text term that describes the kind of surgical treatment administered.	False		String	R0 resection Optimal cytoreduction Sub-optimal cytoreduction Other unknown Data not available
Ovarian Cancer Platinum Status	Ovarian Cancer Tier 3	Text term to indicate the status of treatment with platinum in participant with ovarian cancer	False		String	Platinum-refractory Platinum-sensitive Platinum-resistant Data not available unknown
Pancreas Precancer Histopathologic Grade	Pancreatic Cancer Tier 3	The grade of precancerous pancreatic tissue based on microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.	False		String	IPMN-Adenoma IPMN-Borderline IPMN-Carcinoma in situ IPMN-Invasive carcinoma PanIN 1 PanIN 1A PanIN 1B PanIN 2 PanIN 3 unknown Not Reported
Pancreatic IPMN Pathology Epithelial Subtype	Pancreatic Cancer Tier 3	The Intraductal Papillary Mucinous Neoplasm (IPMN) epithelial cell subtype based on the gross and microscopic examination of a pancreatic neoplasm specimen	False		String	Gastric Foveolar Intestinal Intraductal Tubopapillary Pancreatobiliary Oncocytic Other unknown Not Reported
Pancreatic Duct Final Pathology Type	Pancreatic Cancer Tier 3	The final pathology result of the pancreatic duct communication type.	False		String	Side-Branch Main Duct Mixed Not Specified None Not Reported
Location Extent Extraprostatic Extension	Prostate Cancer Tier 3	Location and extent of extraprostatic extension	False		String	Left Anterior Left Lateral Left Posterolateral Left Posterior Left Apex Left Mid Left Base Left Focal Left Non-focal (established) Right Anterior Right Lateral Right Posterolateral Right Posterior Right Apex Right Mid Right Base Right Focal Right Non-focal (established) unknown Not Reported
Location Nature Positive Margins	Prostate Cancer Tier 3	Location and nature of positive margins	False		String	Left Anterior Left Lateral Left Posterolateral Left Posterior Left Apex Left Mid Left Base Left Focal Left Extensive Left Positive in an area of extraprostatic extension (EPE) Left Positive in an area of intraprostatic incision (II) Left Positive where it is difficult to distinguish EPE vs II Right Anterior Right Lateral Right Posterolateral Right Posterior Right Apex Right Mid Right Base Right Focal Right Extensive Right Positive in an area of extraprostatic extension (EPE) Right Positive in an area of intraprostatic incision (II) Right Positive where it is difficult to distinguish EPE vs II Bladder neck (block PUM) Vas deferens Apical margin (block DUM) unknown Not Reported
Seminal Vesicle Invasion	Prostate Cancer Tier 3	An anatomic position identifying a side of the body where local spread of malignant neoplasm is found to infiltrate tissue in the saclike glandular diverticulum on the ductus deferens in a male.	False		String	None Left Right Both sides unknown Not Reported
Prostate Carcinoma Histologic Type	Prostate Cancer Tier 3	The diagnostic subclassification of an invasive prostate carcinoma.	False		String	Prostatic adenocarcinoma (conventional NOS) Prostatic duct adenocarcinoma Acinar prostate mucinous (colloid) adenocarcinoma Acinar prostate adenocarcinoma-signet-ring variant Prostatic adenosquamous carcinoma Acinar prostate mucinous adenocarcinoma Prostatic small cell carcinoma Acinar prostate adenocarcinoma-sarcomatoid variant Undifferentiated carcinoma NOS Other
Prostate Cancer Local Extent	Prostate Cancer Tier 3	The response used to categorize the local extent of disease for prostate cancer.	False		String	Organ Confined Extraprostatic extension unknown Not Reported
Additonal Findings Uninvolved Prostate	Prostate Cancer Tier 3	Additional findings, uninvolved prostate	False		String	High-grade prostatic intraepithelial neoplasia (PIN) Inflammation Benign prostatic hyperplasia (BPH) Prostatic Intraductal adenocarcinoma Other unknown Not Reported
Prostate Cancer Cytologic Morphologic Subtypes	Prostate Cancer Tier 3	Text term that describes various morphological and cytological subtypes in protate tumors.	False		String	prostatic basal cell hyperplasia prostatic clear cell cribiform hyperplasia prostatic atypical adenomatous hyperplasia (adenosis or AAH) Low grade prostatic intraepithelial neoplasia (PIN)/(PIN I) High grade prostatic intraepithelial neoplasia (HGPIN)/ (PIN II & PIN III) Other unknown Not Reported
Sarcoma Subtype	Sarcoma Tier 3	The subtype related to the scientific determination and investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms of tissue growth resulting from uncontrolled cell proliferation.	False		String	Undifferentiated pleomorphic sarcoma Leiomyosarcoma (uterine or extra-uterine) Other Synovial Sarcoma Or Malignant Peripheral Nerve Sheath Tumor Sarcoma Gastrointestinal Stromal Tumor Liposarcoma undifferentiated pleomorphic sarcoma or malignant fibrous histiosarcoma Other unknown Not Reported
Sarcoma Diagnosis Classification Category	Sarcoma Tier 3	High level grouping to describe a diagnostic grouping or category for sarcoma, a malignant mesenchymal cell tumor most commonly arising from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels.	False		String	Bone Sarcoma Musculoskeletal Sarcoma Soft Tissue Sarcoma unknown Not Reported
Sarcoma Tumor Extension Type	Sarcoma Tier 3	The field to indicate the organs and structures to which the tumor has become adherent or has invaded.	False		String	Extraosseous Intracranial Lymph nodes Parameningeal Thoracic cavity Other unknown Not Reported
Alive	Demographics	This indicates the participant is alive and defines further required metadata	False		String	
Medically Underserved Area - Yes	Clinical Data Tier 2	Patient's zip code is in a medically underserved area	False		String	
Medically Underserved Area - No	Clinical Data Tier 2	Patient's zip code is not in a medically underserved area	False		String	
Medically Underserved Area - Unknown	Clinical Data Tier 2	Insufficient data to look up the Medically Underserved Area value	False		String	
Days to Vital Status Reference	Demographics	Number of days between the date used for index and the reference date for designation of vital status	True	Vital Status is "Alive"	String	
Medically Underserved Score	Clinical Data Tier 2	Index of Medical Underservice (IMU) score, a number between 0 and 100, where 0 represents completely underserved and 100 represents best served or least underserved. Use patient zip code to find the county the patient lives in by going to https://www.unitedstateszipcodes.org/. Enter the zip code in the main text field and use the asociated county on the right side of the result field. Go to data.hrsa.gov website and select Query Data. Pick the Medically Underserved Areas/Populations (MUA/P) data source in the step 1 menu and select View Data. Enter the name of the county (______ county) in the first "Service Area" column, adding the state in the 5th column may help direct you to the data. Enter the Index of Medical Underservice Score in the fourth column to one decimal place as the value.	False		String