# Specific Standards

HTAN Centers submit assay data files and metadata to HTAN. HTAN's Data Model governs how the assay data is organized and what metadata accompanies the assay data.

HTAN Centers submit their metadata in spreadsheets called manifests. The HTAN Portal's Data Standards pages provide interactive, searchable and downloadable summaries of the metadata attributes, requirements and valid values expected for each data type.

The following table provides links to specific manifests within the Data Standards pages.

# Table of Specific Standards

Category	Specific Standard
Biospecimen	Biospecimen
Clinical	Demographics
Clinical	Diagnosis
Clinical	Exposure
Clinical	Family History
Clinical	Follow Up
Clinical	Molecular Test
Clinical	Therapy
Clinical	Clinical Data Tier 2
Clinical	Acute Lymphoblastic Leukemia Tier 3
Clinical	Breast Cancer Tier 3
Clinical	Colorectal Cancer Tier 3
Clinical	Lung Cancer Tier 3
Clinical	Melanoma Tier 3
Clinical	Ovarian Cancer Tier 3
Clinical	Pancreatic Cancer Tier 3
Clinical	Pancreatic Cancer Tier 3
Clinical	Prostate Cancer Tier 3
Clinical	Sarcoma Tier 3
Imaging	Imaging Level 1
Imaging	Imaging Level 2
Imaging	Imaging Level 3
Imaging	Imaging Level 4
Mass Spectrometry	Mass Spectrometry Level 1
Mass Spectrometry	Mass Spectrometry Level 2
Mass Spectrometry	Mass Spectrometry Level 3
Mass Spectrometry	Mass Spectrometry Level 4
Mass Spectrometry	Mass Spectrometry Auxiliary File
Proteomics	RPPA Level 2
Proteomics	RPPA Level 3
Proteomics	RPPA Level 4
Sequencing	Bulk DNA Level 1
Sequencing	Bulk DNA Level 2
Sequencing	Bulk DNA Level 3
Sequencing	Bulk Methylation-seq Level 1
Sequencing	Bulk Methylation-seq Level 2
Sequencing	Bulk Methylation-seq Level 3
Sequencing	Bulk RNA-seq Level 1
Sequencing	Bulk RNA-seq Level 2
Sequencing	Bulk RNA-seq Level 3
Sequencing	Hi-C-seq Level 1
Sequencing	Hi-C-seq Level 2
Sequencing	Hi-C-seq Level 3
Sequencing	scATAC-seq Level 1
Sequencing	scATAC-seq Level 2
Sequencing	scATAC-seq Level 3
Sequencing	scATAC-seq Level 3
Sequencing	scDNA-seq Level 1
Sequencing	scDNA-seq Level 2
Sequencing	scmC-seq Level 1
Sequencing	scmC-seq Level 2
Sequencing	scRNA-seq Level 1
Sequencing	scRNA-seq Level 2
Sequencing	scRNA-seq Level 3
Sequencing	scRNA-seq Level 4
Spatial Transcriptomics	10X Genomics Xenium ISS Experiment
Spatial Transcriptomics	10x Visium Spatial Transcriptomics - RNA-seq Level 1
Spatial Transcriptomics	10x Visium Spatial Transcriptomics - RNA-seq Level 2
Spatial Transcriptomics	10x Visium Spatial Transcriptomics - RNA-seq Level 3
Spatial Transcriptomics	10x Visium Spatial Transcriptomics - Auxiliary Files
Spatial Transcriptomics	Nanostring CosMx SMI Experiment
Spatial Transcriptomics	NanoString GeoMx DSP ROI DCC Segment Annotation Metadata
Spatial Transcriptomics	NanoString GeoMx DSP ROI RCC Segment Annotation Metadata
Spatial Transcriptomics	NanoString GeoMx DSP Spatial Transcriptomics Level 1
Spatial Transcriptomics	NanoString GeoMx DSP Spatial Transcriptomics Level 3
Spatial Transcriptomics	Slide-seq Level 1
Spatial Transcriptomics	Slide-seq Level 2
Spatial Transcriptomics	Slide-seq Level 3

# Data Submission

While Data Standards provides details regarding the HTAN Data Model, the manifests included on the HTAN Portal are for reference only.

⚠️

HTAN Centers should not use the manifests provided on the Data Standards page for data submission. Please use the Data Curator App (DCA) to obtain manifests for data submission. More information about submitting assay files and metadata can be found in the Submitting Data section of this manual.

For additional notes regarding how to submit data for each data type, please see the Specific Assay/Data Element Details page of this manual.